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A patent review of xanthine oxidase inhibitors (2021-present).
Expert Opin Ther Pat
December 2024
Key Laboratory of Structure-Based Drugs Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, China.
Introduction: Xanthine oxidase (XO) catalyzes the oxidation of both hypoxanthine and xanthine in the last two steps of the purine metabolic pathway, serving as a rate-limiting enzyme for uric acid production as well as a key target for the treatment of gout and other hyperuricemia-related conditions.
Areas Covered: This paper reviews XO inhibitors in patents from 2021 to the present. We summarize in detail the structural classes and characteristics, in vitro and in vivo biological results, and structure‒activity relationships of synthetic inhibitors, as well as the sources, specific structures, research methods, and biological activities of XO inhibitors from natural products.
<b>Background and Objective:</b> Prolonged utilization of chemical fertilizers can harm the soil and disturb the equilibrium of nutrients, resulting in a decline in cherry tomato yield. To enhance the growth of cherry tomato plants, it is necessary to add organic chemicals. The research aimed to determine the best elicitor biosaka concentration to apply to evoke the plant growth of cherry tomatoes (<i>Solanum lycopersicum</i> L.
View Article and Find Full Text PDF<b>Background and Objective:</b> Todolo coffee (<i>Coffea arabica</i> L. var. typica) is the oldest commercially grown coffee in the Toraja region of South Sulawesi and is currently at risk of extinction.
View Article and Find Full Text PDFOne-Pot Synthesis of Oxygen Vacancy-Rich Amorphous/Crystalline Heterophase CaWO Nanoparticles for Enhanced Radiodynamic-Immunotherapy.
Adv Sci (Weinh)
December 2024
New Cornerstone Science Laboratory, MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350108, China.
Radiodynamic therapy that employs X-rays to trigger localized reactive oxygen species (ROS) generation can tackle the tissue penetration issue of phototherapy. Although calcium tungstate (CaWO) shows great potential as a radiodynamic agent benefiting from its strong X-ray absorption and the ability to generate electron-hole (e-h) pairs, slow charge carrier transfer and fast e-h recombination greatly limit its ROS-generating performance. Herein, via a one-pot wet-chemical method, oxygen vacancy-rich amorphous/crystalline heterophase CaWO nanoparticles (Ov-a/c-CaWO NPs) with enhanced radiodynamic effect are synthesized for radiodynamic-immunotherapy of cancer.
View Article and Find Full Text PDFSpatially Selective Imaging in Color: What You See is What You Want.
Adv Sci (Weinh)
December 2024
Engineering Product Development, Singapore University of Technology and Design, Singapore, 487372, Singapore.
Spatially selective imaging (SSI) involves sampling a group of pixels from different positions on an encoded object to display a decoded image. Here, SSI is achieved by using off-axis cylindrical Fresnel lens arrays to decode multiple images from an encoded print of structural color pixels. Each image is optically retrieved by separately placing different "keys" (arrays of lenses in different pseudorandom configurations) over the same encoded print, and then each image is digitally reconstructed for visualization.
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