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Updated genetic background of generalized pustular psoriasis as an autoinflammatory keratinization disease.
J Dermatol
December 2024
Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Generalized pustular psoriasis (GPP) is a severe autoinflammatory keratinization disease (AiKD) characterized by acute flares of widespread sterile pustules and high fever. GPP is potentially life-threatening. Recently clarified genetic predisposing factors for GPP suggest that the excessive activation of innate immune pathways in the skin, including of interleukin (IL)-1 and IL-36 signaling, plays a significant role in the GPP pathogenesis.
View Article and Find Full Text PDFAnalysis of the role of IL-1 family and related genes in head and neck squamous cell carcinoma.
Braz J Otorhinolaryngol
September 2024
Beijing Tongren Hospital, Capital Medical University, Beijing, China. Electronic address:
Objective: The Interleukin-1 (IL-1) family plays an important regulatory role in the development of tumors, but its function is still unclear in head and neck squamous cell carcinoma (HNSCC). Analyzing the IL-1 family can help to understand the tumor mechanism.
Methods: Using GEPIA2, UALCAN, cBioprotocol and HPA databases, the IL-1 family and related genes (IL-1α, IL-1β, IL1RN, IL1R1, IL1R2, IL1RL1, IL1RL2, IL1RAP, IL1RAPL1, IL1RAPL2, IL1F10, IL18, IL18BP, IL18R1, IL18RAP, IL36A, IL36B, IL36G, IL36RN, IL33, IL37, SIGIRR, CASP1, AIM2) were analyzed for their expression and prognostic relevance in HNSCC.
Transcriptome Analysis of Porphyromonas gingivalis Lipopolysaccharide-Induced Early Gene Expression in Human Gingival Keratinocytes.
J Periodontal Res
October 2024
Department of Oral Biological and Medical Sciences, Faculty of Dentistry, The University of British Columbia, Vancouver, British Columbia, Canada.
Aim: Porphyromonas gingivalis lipopolysaccharide (PgLPS) is a significant virulence factor and a driver of early innate immune responses in epithelial cells. The presence of PgLPS in immediate proximity to gingival epithelium induces significant inflammatory responses. In primary human gingival keratinocytes (HGK), we utilized transcriptome analysis to elucidate the change in early gene expression induced by PgLPS.
View Article and Find Full Text PDFIL36RN Mutations and Correlated Characteristics in Generalized Pustular Psoriasis Patients in Can Tho City, Vietnam: A Cross-Sectional Study.
Dermatology
December 2024
Department of Dermato-Venereology, Faculty of Medicine, Can Tho University of Medicine and Pharmacy, Can Tho, Vietnam.
Article Synopsis
- Pustular psoriasis is a severe form of psoriasis marked by pustules on red skin, with generalized cases being life-threatening; this study focuses on the genetic mutations (specifically IL36RN) related to the disease in Vietnam.* -
- Conducted at Can Tho Dermatology Hospital, the research involved 59 patients and revealed that a significant number had previous psoriasis; the most common IL36RN mutation found was p.Arg10ArgfsX1, present in nearly half the participants.* -
- The study concluded that IL36RN mutations are prevalent among Vietnamese patients with pustular psoriasis and are linked to symptoms like fever and geographic tongue, suggesting important implications for treatment and understanding of the disease.*
TLR7/8 Activation in Immune Cells and Muscle by RNA-Containing Immune Complexes: Role in Inflammation and the Pathogenesis of Myositis.
Arthritis Rheumatol
September 2024
EMD Serono, Billerica, Massachusetts.
Objective: Activation of endosomal toll-like receptors (TLRs) is one possible driver of inflammation in idiopathic inflammatory myopathies (IIM). We investigated the potential contribution of TLR7 and TLR8 to IIM pathogenesis.
Methods: Activation of TLR7/8 in healthy donor peripheral blood mononuclear cells (PBMCs) by immune complexes from patients with IIMs and lupus was tested.
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