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Postepy Biochem
December 2024
Department of Genetics and Clinical Immunology, Institute of Tuberculosis and Lung Diseases, Warsaw, Poland.
Rak trzustki jest często występującym nowotworem o bardzo złych rokowaniach i agresywnym przebiegu. Podstawową przyczyn wysoce niekorzystnych rokowań pacjentów z rakiem trzustki jest jego długotrwale bezobjawowy rozwój, co powoduje postawienie diagnozy na etapie znacznego zaawansowania procesu nowotworowego. Pomimo szeroko zakrojonych badań nad uskutecznieniem diagnostyki i leczenia tego nowotworu, przeżywalność pacjentów wzrasta powoli i nieznacznie.
View Article and Find Full Text PDFRisk Factors Related to Resting Metabolic Rate-Related Gene Variation in Children with Overweight/Obesity: 3-Year Panel Study.
Nutrients
December 2024
Department of Food & Nutrition & Research Institute of Obesity Sciences, Sungshin Women's University, Dobongro-76gagil-55, Kangbuk-ku, Seoul 01133, Republic of Korea.
Unlabelled: This study investigated how the gene variation related to RMR alteration affects risk factors of obese environments in children with obesity aged 8-9.
Methods: Over a three-year follow-up period, 63.3% of original students participated.
Associations of Coffee and Tea Consumption on Neural Network Connectivity: Unveiling the Role of Genetic Factors in Alzheimer's Disease Risk.
Nutrients
December 2024
Department of Neurology, Rutgers University, New Brunswick, NJ 08854, USA.
Background: Coffee and tea are widely consumed beverages, but their long-term effects on cognitive function and aging remain largely unexplored. Lifestyle interventions, particularly dietary habits, offer promising strategies for enhancing cognitive performance and preventing cognitive decline.
Methods: This study utilized data from the UK Biobank cohort ( = 12,025) to examine the associations between filtered coffee, green tea, and standard tea consumption and neural network functional connectivity across seven resting-state networks.
Association of Metabolic Diseases and Moderate Fat Intake with Myocardial Infarction Risk.
Nutrients
December 2024
Department of Food and Nutrition, Obesity/Diabetes Research Center, Hoseo University, 20 Hoseoro97bungil, BaeBang-Yup, Asan 31499, Republic of Korea.
Background: Myocardial infarction (MI) can range from mild to severe cardiovascular events and typically develops through complex interactions between genetic and lifestyle factors.
Objectives: We aimed to understand the genetic predisposition associated with MI through genetic correlation, colocalization analysis, and cells' gene expression values to develop more effective prevention and treatment strategies to reduce its burden.
Methods: A polygenic risk score (PRS) was employed to estimate the genetic risk for MI and to analyze the dietary interactions with PRS that affect MI risk in adults over 45 years ( = 58,701).
Genomic Insights into Host Susceptibility to Periprosthetic Joint Infections: A Comprehensive Literature Review.
Microorganisms
December 2024
Orthopedic Surgery Department, Cleveland Clinic, Weston, FL 33331, USA.
Periprosthetic joint infection (PJI) is a multifactorial disease, and the risk of contracting infection is determined by the complex interplays between environmental and host-related factors. While research has shown that certain individuals may have a genetic predisposition for PJI, the existing literature is scarce, and the heterogeneity in the assessed genes limits its clinical applicability. Our review on genetic susceptibility for PJI has the following two objectives: (1) Explore the potential risk of developing PJI based on specific genetic polymorphisms or allelic variations; and (2) Characterize the regulatory cascades involved in the risk of developing PJI.
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