Chronic salicylate poisoning is often seen in elderly patients as a result of an unintended overdosage, a change in metabolism or kidney function. The symptoms are often unspecific. This case report is about a 55-year-old man who was unconscious when admitted to hospital, and who died three hours after admission. An autopsy and a toxicological test showed a deadly level of salicylate in his blood. Afterwards, his wife told that he had complained about a sudden hearing loss, and that his behaviour had changed prior to his death. It is important to keep this diagnosis in mind when treating especially elderly patients.
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Theranostics
January 2025
Medicinal Materials Research Center, Biomedical Research Division, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea.
Acute liver failure (ALF) is characterized by rapid hepatic dysfunction, primarily caused by drug-induced hepatotoxicity. Due to the lack of satisfactory treatment options, ALF remains a fatal clinical disease, representing a grand challenge in global health. For the drug repositioning to ALF of mesalamine, which is clinically approved for the treatment of inflammatory bowel disease (IBD), we propose a supramolecular prodrug nanoassembly (SPNs).
View Article and Find Full Text PDFEnviron Pollut
December 2024
Department of Botany, GDC-Pulwama-192301, Jammu and Kashmir, India. Electronic address:
The present study uncovers the impacts of pesticide-thiamethoxam (TMX- 750 mg L) and salicylic acid (SA- 0.01, 0.1 and 1 mM) in Brassica juncea L.
View Article and Find Full Text PDFJ Emerg Med
December 2024
Department of Emergency Medicine, Division of Toxicology, NYC Health + Hospitals/Jacobi, Bronx, New York.
J Emerg Med
December 2024
Division of Medical Toxicology, Department of Emergency Medicine, Washington University School of Medicine, Saint Louis, Missouri. Electronic address:
Food Chem X
December 2024
State Key Laboratory of Green Pesticides, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R&D of Fine Chemicals of Guizhou University, Guiyang 550025, China.
Salicylic acid (SA) is widely used in food storage, preservatives, additives, healthcare, and the pharmaceutical industry. However, various poisoning symptoms are frequently reported upon ingestion of a large amount of SA. Therefore, discovering new tools for sensing SA with fast, simple, and portable performance is imperative.
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