Supramolecular nanosubstrate-mediated delivery for reprogramming and transdifferentiation of mammalian cells.

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Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging (CIMI), California NanoSystems Institute (CNSI), University of California, Los Angeles, CA, 90095-1770, USA.

Published: June 2015

Supramolecular nanosubstrate-mediated delivery (SNSMD) leverages the power of molecular self-assembly and a nanostructured substrate platform for the low toxicity, highly efficient co-delivery of biological factors encapsulated in a nanovector. Human fibroblasts are successfully reprogrammed into induced pluripotent stems and transdifferentiated into induced neuronal-like cells.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4961214PMC
http://dx.doi.org/10.1002/smll.201402602DOI Listing

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