Arterial hypertension is a highly prevalent disease and its secondary causes must always be kept in mind because the treatment and prognosis differ between these and essential hypertension. Here we present the first reported case in Argentina of a 21-year-old patient with arterial hypertension and hypokalaemia due to a renin-secreting juxtaglomerular cell tumour, which was diagnosed after seven years of development.
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Renal Juxtaglomerular Cell Tumors Exhibit Distinct Genomic and Epigenomic Features and Lack Recurrent Gene Fusions: Comprehensive Molecular Analysis of a Multi-institutional Series.
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Department of Pathology, Indiana University School of Medicine, Indianapolis, IN.
Juxtaglomerular cell tumor (JxGCT) is a rare type of renal neoplasm demonstrating morphologic overlap with some mesenchymal tumors such as glomus tumor (GT) and solitary fibrous tumor (SFT). Its oncogenic drivers remain elusive, and only a few cases have been analyzed with modern molecular techniques. In prior studies, loss of chromosomes 9 and 11 appeared to be recurrent.
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Division of Pediatric Nephrology, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA.
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View Article and Find Full Text PDFJuxtaglomerular Cell Tumor With Cytohistological Correlation: A Case Report.
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University of Virginia School of Medicine Inova Campus, Falls Church, Virginia, USA.
Juxtaglomerular cell tumors (JCT) are uncommon renin-secreting tumors of the kidney with cytologic findings of JCT rarely reported. We describe a case of JCT in a 37-year-old man with uncontrolled hypertension that was cured by removal of the tumor via partial nephrectomy. Cytology material was prepared by scraping of the freshly sectioned tumor mass and stained with Diff-Quik and Papanicolaou stains.
View Article and Find Full Text PDFPiezo channels in JG cells do not regulate renin expression or renin release to the circulation.
Clin Sci (Lond)
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Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, VA, U.S.A.
Article Synopsis
- Renin-expressing juxtaglomerular (JG) cells have a mechanism that senses pressure and regulates renin release based on changes in blood flow.
- The study investigates whether Piezo2 receptors, known for their role in detecting touch, play a role in controlling renin synthesis and release in JG cells.
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November 2024
Department of Endocrinology and metabolism, Guangzhou Red Cross Hospital of Jinan University, No. 396, Tong Fu Zhong Rd, Guangzhou, 510220, China.
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