AI Article Synopsis
- Sentinel lymph nodes (SLNs) are key locations for observing how cancer spreads, as they receive lymph fluid containing immune factors and tumor cells from primary melanomas.
- These immune-suppressed SLNs have fewer immune cells like dendritic cells and activated T cells, making them valuable for researching how tissues are susceptible to metastases.
- The article also suggests that SLNs can help study ways to reverse the immune suppression caused by tumors, building on findings from a 2006 Nature Reviews of Immunology paper and current research.
Article Abstract
Sentinel lymph nodes (SLNs), the initial site of regional metastases, directly receive lymph containing immune-modulatory cytokines and tumor cells from primary melanomas. Immune-suppressed SLNs are ideal for studies of tissue susceptibility to metastases. They show reduced antigen-presenting dendritic cells, activated T cells, high endothelial venules, and transvenular immigration of T cells. Tumor-induced immune suppression contributes to establishment of nodal metastases. SLNs may serve as an effective model to study reversal of tumor-induced immune suppression. We reviewed this topic in Nature Reviews of Immunology in 2006. We here summarize the Nature paper and provide additional results from ongoing studies and the recent literature.
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| http://dx.doi.org/10.1097/PPO.0000000000000094 | DOI Listing |
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