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Thoracic Sertoli-Leydig cell tumor: An alternative type of pleuropulmonary blastoma associated with DICER1 variation.
Pediatr Blood Cancer
November 2021
International PPB/DICER1 Registry, Children's Minnesota, Minneapolis, Minnesota, USA.
A 2-year-old boy presented with a large cystic and solid chest mass arising from the lung, radiographically consistent with pleuropulmonary blastoma (PPB). He underwent right lower lobectomy with resection of a well-circumscribed, mixed solid and cystic mass. The solid areas were composed of cords and nests of tumor cells in the myxoid stroma and retiform foci whose pathologic and immunophenotypic findings were consistent with a sex cord-stromal tumor with features of a Sertoli-Leydig cell tumor.
View Article and Find Full Text PDFFactors that influence physician decision making for indeterminate pulmonary nodules.
Ann Am Thorac Soc
December 2014
1 Department of Medicine, Division of Pulmonary, Allergy, and Critical Care, University of Pennsylvania, Philadelphia, Pennsylvania.
Rationale: Pulmonologists frequently encounter indeterminate pulmonary nodules in practice, but it is unclear what clinical factors they rely on to guide the diagnostic evaluation.
Objectives: To assess the current approach to the management of indeterminate pulmonary nodules and to determine the extent to which the addition of a hypothetical diagnostic blood test will influence clinical decision making.
Methods: Selected pulmonologists practicing in the United States were invited to participate in a conjoint exercise based on 20 randomly generated cases of varying age, smoking history, and nodule size.
Minimally invasive endoscopic therapy for the management of Boerhaave's syndrome.
Ann R Coll Surg Engl
November 2013
NHS Lanarkshire, c/o Hasan Kasem at Wishaw General Hospital, 50 Netherton Street, Wishaw, North Lanarkshire ML2 0DP, UK.
Introduction: Boerhaave's syndrome represents the most lethal of all gastrointestinal perforations. In 2009 a treatment algorithm was published based on current level 4 evidence indicating that all septic patients should be treated surgically, early presentations without sepsis endoscopically and delayed presentations without sepsis conservatively. No provision was made for septic patients unfit for surgical intervention.
View Article and Find Full Text PDFHistory of surgery for atrial fibrillation.
Heart Rhythm
December 2009
Heart Hospital Baylor Plano, Cardiopulmonary Research, Science, and Technology Institute, Plano, Texas, USA.
There is a rich history of surgery for atrial fibrillation. Initial procedures were aimed at controlling the ventricular response rate. Later procedures were directed at converting atrial fibrillation to normal sinus rhythm.
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