AI Article Synopsis
- The study explored how left ventricular hypertrophy (LVH) affects the release of cardiac biomarkers during myocardial infarction (MI) in both patients and pigs.
- Results showed that LVH led to significantly higher levels of cardiac troponin I (cTnI) post-MI, but did not influence total creatine kinase (CK) levels or the estimation of infarct size (IS) using CK.
- The findings indicate that cTnI may overestimate IS in patients with LVH and is not reliable for predicting post-infarction left ventricular dysfunction, suggesting the need to consider LV mass when evaluating IS and cardiac health.
Article Abstract
Background: Biomarkers are frequently used to estimate infarct size (IS) as an endpoint in experimental and clinical studies. Here, we prospectively studied the impact of left ventricular (LV) hypertrophy (LVH) on biomarker release in clinical and experimental myocardial infarction (MI).
Methods And Results: ST-segment elevation myocardial infarction (STEMI) patients (n=140) were monitored for total creatine kinase (CK) and cardiac troponin I (cTnI) over 72 hours postinfarction and were examined by cardiac magnetic resonance (CMR) at 1 week and 6 months postinfarction. MI was generated in pigs with induced LVH (n=10) and in sham-operated pigs (n=8), and serial total CK and cTnI measurements were performed and CMR scans conducted at 7 days postinfarction. Regression analysis was used to study the influence of LVH on total CK and cTnI release and IS estimated by CMR (gold standard). Receiver operating characteristic (ROC) curve analysis was performed to study the discriminatory capacity of the area under the curve (AUC) of cTnI and total CK in predicting LV dysfunction. Cardiomyocyte cTnI expression was quantified in myocardial sections from LVH and sham-operated pigs. In both the clinical and experimental studies, LVH was associated with significantly higher peak and AUC of cTnI, but not with differences in total CK. ROC curves showed that the discriminatory capacity of AUC of cTnI to predict LV dysfunction was significantly worse for patients with LVH. LVH did not affect the capacity of total CK to estimate IS or LV dysfunction. Immunofluorescence analysis revealed significantly higher cTnI content in hypertrophic cardiomyocytes.
Conclusions: Peak and AUC of cTnI both significantly overestimate IS in the presence of LVH, owing to the higher troponin content per cardiomyocyte. In the setting of LVH, cTnI release during STEMI poorly predicts postinfarction LV dysfunction. LV mass should be taken into consideration when IS or LV function are estimated by troponin release.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330053 | PMC |
| http://dx.doi.org/10.1161/JAHA.114.001218 | DOI Listing |
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