The accuracy performance of fringe projection profilometry (FPP) depends on accurate phase-to-height (PTH) mapping and system calibration. The existing PTH mapping is derived based on the condition that the plane formed by axes of camera and projector is perpendicular to the reference plane, and measurement error occurs when the condition is not met. In this paper, a new geometric model for FPP is presented to lift the condition, resulting in a new PTH mapping relationship. The new model involves seven parameters, and a new system calibration method is proposed to determine their values. Experiments are conducted to verify the performance of the proposed technique, showing a noticeable improvement in the accuracy of 3D shape measurement.
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http://dx.doi.org/10.1364/OE.22.032220 | DOI Listing |
Bone Res
October 2024
Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
Denosumab is a monoclonal anti-RANKL antibody that inhibits bone resorption, increases bone mass, and reduces fracture risk. Denosumab discontinuation causes an extensive wave of rebound resorption, but the cellular mechanisms remain poorly characterized. We utilized in situ hybridization (ISH) as a direct approach to identify the cells that activate osteoclastogenesis through the RANKL/OPG pathway.
View Article and Find Full Text PDFInt J Mol Sci
August 2024
Takeda Development Center Americas Inc., Cambridge, MA 02142, USA.
Type 1 Gaucher disease (GD1) is a rare, autosomal recessive disorder caused by glucocerebrosidase deficiency. Skeletal manifestations represent one of the most debilitating and potentially irreversible complications of GD1. Although imaging studies are the gold standard, early diagnostic/prognostic tools, such as molecular biomarkers, are needed for the rapid management of skeletal complications.
View Article and Find Full Text PDFAnal Chem
March 2024
Pharmaceutical Biochemistry and Bioanalytics, Pharmaceutical Institute, University of Bonn, Bonn 53121, Germany.
Disulfide bridges in peptides and proteins play an essential role in maintaining their conformation, structural integrity, and consequently function. Despite ongoing efforts, it is still not possible to detect disulfide bonds and the connectivity of multiply bridged peptides directly through a simple and sufficiently validated protein sequencing or peptide mapping method. Partial or complete reduction and chemical cysteine modification are required as initial steps, followed by the application of a proper detection method.
View Article and Find Full Text PDFBrachydactyly type E (BDE), shortened metacarpals, metatarsals, cone-shaped epiphyses, and short stature commonly occurs as a sole phenotype. Parathyroid hormone-like protein (PTHrP) has been shown to be responsible in all forms to date, either directly or indirectly. We used linkage and then whole genome sequencing in a small pedigree, to elucidate BDE and identified a truncated disintegrin-and-metalloproteinase-19 (ADAM19) allele in all affected family members, but not in nonaffected persons.
View Article and Find Full Text PDFHealth Sci Rep
November 2023
Oli Health Magazine Organization, Research and Education Kigali Rwanda.
Background: Hydrocephalus or ventriculomegaly is a condition brought on by an overabundance of cerebrospinal fluid (CSF) in the ventricular system. The major contributor to posttraumatic hydrocephalus (PTH) is traumatic brain injuries (TBIs), especially in individuals with occupations set in industrial settings. A variety of criteria have been employed for the diagnosis of PTH, including the combination of neurological symptoms like nerve deficits and headache, as well as an initial improvement followed by a worsened relapse of altered consciousness and neurological deterioration, which is detected by computed tomography-brain imaging that reveals gradual ventriculomegaly.
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