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Postoperative Radiotherapy for pT1- and pT2-Classified Squamous Cell Carcinoma of the External Auditory Canal.
Cancers (Basel)
November 2024
Department of Otorhinolaryngology and Head and Neck Surgery-Academic Alliance Skull Base Pathology Radboudumc & MUMC+, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
Background: There is no consensus regarding the indication for postoperative radiotherapy (PORT) for T1- and T2-classified squamous cell carcinoma (SCC) of the external auditory canal (EAC) even with negative surgical margins. This study aimed to evaluate whether PORT provides additional benefits for these cases.
Methods: We collected retrospective data from fourteen international hospitals, including resected pT1- and pT2-classified EAC SCC with negative surgical margins.
Development of a Preclinical Double Model of Mandibular Irradiated Bone and Osteoradionecrosis in New Zealand Rabbits.
Head Neck
February 2025
Guided Therapeutics (GTx) Program, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.
Purpose: Radiotherapy (RT) plays a crucial role in head and neck (HN) cancer treatment. Nevertheless, it can lead to serious and challenging adverse events such as osteoradionecrosis (ORN). A preclinical rabbit model of irradiated bone and ORN is herein proposed, with the aim to develop a viable model to be exploited for investigating new therapeutic approaches.
View Article and Find Full Text PDFLateral skull-base osteoradionecrosis: a 15-year series of 20 consecutive cases and a suggested management protocol.
J Laryngol Otol
August 2024
ENT Department, Queen Elizabeth Hospital Birmingham, University Hospital Birmingham NHS Foundation Trust, Birmingham, UK.
Background: Temporal bone osteoradionecrosis is a rare but significant complication of radiation for head and neck malignancies. Various management techniques have been described, but no clear protocol exists.
Methods: A retrospective case review of patients with temporal bone osteoradionecrosis managed over 15 years was carried out to highlight multidisciplinary team (MDT) management.
Exploring Prevalence Trends of Jaw Bone Pathologies: A Three-Year Institutional Study.
Cureus
May 2024
Oral and Maxillofacial Surgery, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, IND.
Background Head and neck bone pathologies cover various conditions with diverse causes. Infections like osteomyelitis and dental abscesses can spread to soft tissues and bones, causing tissue death, inflammation, and systemic effects. Benign and malignant tumors can develop from soft tissue, cartilage, or bone, posing challenges for diagnosis and treatment.
View Article and Find Full Text PDFSurvival outcomes and toxicity profiles among patients with nonmetastatic nasopharyngeal carcinoma treated with intensity-modulated radiotherapy (IMRT) versus IMRT + carbon-ion radiotherapy: A propensity score-matched analysis.
Head Neck
July 2024
Department of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Fudan University Cancer Hospital, Shanghai, China.
Article Synopsis
- The study aimed to compare survival outcomes and side effects in patients with nonmetastatic nasopharyngeal carcinoma treated with either intensity-modulated radiotherapy (IMRT) or a combination of IMRT and carbon-ion radiotherapy (CIRT).
- A total of 109 patients were analyzed, with results showing no significant differences in survival rates between the two treatment groups, although the IMRT + CIRT group may have better outcomes.
- Patients receiving IMRT + CIRT experienced lower severity of acute side effects like oral mucositis and dermatitis compared to those who only received IMRT.
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