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Expression of tumor necrosis factor receptor-associated factor 6 in lung cancer tissues. | LitMetric

Expression of tumor necrosis factor receptor-associated factor 6 in lung cancer tissues.

Asian Pac J Cancer Prev

Department of Pathology, First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, China E-mail :

Published: October 2015

AI Article Synopsis

  • TRAF6 protein has been shown to be significantly more expressed in lung cancer tissues compared to normal lung tissues, indicating its potential role in cancer development.
  • A study involving 365 lung cancer samples found that higher TRAF6 levels are associated with advanced clinical stages, larger tumor sizes, and lymph node metastasis.
  • The research suggests that TRAF6 could be targeted for diagnosis and gene therapy in lung cancer patients due to its oncogenic properties.

Article Abstract

Background: Tumor necrosis factor (TNF) receptor-associated factor 6 (TRAF6) has been reported to be associated with the development of various cancers. However, the role of TRAF6 in lung cancer remains unclear.

Objective: To explore the expression and clinicopathological significance of TRAF6 protein in lung cancer tissues.

Materials And Methods: Three hundred and sixty-five lung cancer samples and thirty normal lung tissues were constructed into 3 microarrays. The expression of TRAF6 protein was determined using immunohistochemistry (IHC). Furthermore, correlations between the expression of TRAF6 and clinicopathological parameters were investigated.

Results: The expression of TRAF6 in total lung cancer tissues (365 cases), as well as in small cell lung cancer (SCLC, 26 cases) and non-small cell lung cancer (NSCLC, 339 cases) was significantly higher compared with that in normal lung tissues. The ROC curve showed that the area under curve of TRAF6 was 0.663 (95%CI 0.570~0.756) for lung cancer. The diagnostic sensitivity and specificity of TRAF6 were 52.6% and 80%, respectively. In addition, the expression of TRAF6 was correlated with clinical TNM stage, tumor size and lymph node metastasis in all lung cancers. Consistent correlations were also observed for NSCLCs.

Conclusions: TRAF6 might be an oncogene and the expression of TRAF6 protein is related to the progression of lung cancer. Thus, TRAF6 might become a target for diagnosis and gene therapy for lung cancer patients.

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Source
http://dx.doi.org/10.7314/apjcp.2014.15.24.10591DOI Listing

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