Cerebellar transcranial direct current stimulation (tDCS) has the potential to modulate cerebellar outputs and visuomotor adaptation. The cerebellum plays a pivotal role in the acquisition and control of skilled hand movements, especially its temporal aspects. We applied cerebellar anodal tDCS concurrently with training of a synchronization-continuation motor task. We hypothesized that anodal cerebellar tDCS will enhance motor skill acquisition. Cerebellar tDCS was applied to the right cerebellum in 31 healthy subjects in a double-blind, sham-controlled, parallel design. During synchronization, the subjects tapped the sequence in line with auditory cues. Subsequently, in continuation, the learned sequence was reproduced without auditory cuing. Motor task performance was evaluated before, during, 90 min, and 24 h after training. Anodal cerebellar tDCS, compared with sham, improved the task performance in the follow-up tests (F1,28 = 5.107, P = 0.032) of the synchronization part. This effect on retention of the skill was most likely mediated by enhanced motor consolidation. We provided first evidence that cerebellar tDCS can enhance the retention of a fine motor skill. This finding supports the promising approach of using noninvasive brain stimulation techniques to restore impaired motor functions in neurological patients, such after a stroke.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1093/cercor/bhu335 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Time Dependent Effects of Cerebellar tDCS on Cerebello-cortical Connectivity Networks in Young Adults.
Cerebellum
January 2025
Department of Psychological and Brain Sciences, Texas A&M University, College Station, TX, USA.
The cerebellum is involved in non-motor processing, supported by topographically distinct cerebellar activations and closed-loop circuits between the cerebellum and the cortex. Disruptions to cerebellar function may negatively impact prefrontal function and processing. Cerebellar resources may be important for offloading cortical processing, providing crucial scaffolding for normative performance and function.
View Article and Find Full Text PDFLong-term exercise training reduced the sound-induced flash illusion in multisensory illusions owing to the cerebellum.
Conscious Cogn
January 2025
Department of Psychology, Suzhou University of Science and Technology, Suzhou, China; Department of Psychology, Northeast Nomal University, Changchun, China; Laboratory, Graduate School of Interdisciplinary Science and Engineering In Health Systems, Okayama University, Okayama, Japan. Electronic address:
Sound-induced flash illusion (SiFI) is an auditory-dominant multisensory illusion that can be used to assess multisensory integration. Although previous studies have shown that one-time intervention exercise training does not significantly affect SiFI, the long-term improvement of SiFI with exercise training remains controversial. In the present study, the classical SiFI paradigm was used to investigate the effects of long-term exercise training on the SiFI.
View Article and Find Full Text PDFCerebellar Transcranial AC Stimulation Produces a Frequency-Dependent Bimodal Cerebellar Output Pattern.
Cerebellum
January 2025
Department of Neuroscience and Physiology, Grossman School of Medicine, NYU Neuroscience Institute, New York University, New York, NY, 10016, USA.
Article Synopsis
- ctACS may offer a non-invasive treatment avenue for psychiatric and neurological disorders, but its effectiveness is limited by a lack of understanding of its impact on cerebellar activity at cellular levels.
- Previous research indicated that AC stimulation influenced Purkinje cell (PC) and cerebellar nuclear (CN) cell activity in a frequency-dependent manner when applied to the cerebellum.
- This study found that ctACS altered PC and CN activity in rats, revealing that the modulation patterns varied with stimulus frequency and electrode placement, indicating potential for targeted treatment strategies.
How and where Effectively Apply Cerebellum Stimulation: The frequency-dependent Modulation of Cerebellar Output by Transcranial Alternating Current Stimulation.
Cerebellum
January 2025
Department of Neuroscience, University of Mons, Mons, Belgium.
As brain-machine interfaces (BMI) are growingly used in clinical settings, understanding how to apply brain stimulation is increasingly important. Despite the emergence of optogenetic techniques, ethical and medical concerns suggest that interventions that are safe and non-invasive, such as Transcranial Alternating Current Stimulation (tACS), are more likely to be employed in human in the near future. Consequently, the question of how and where to apply current stimulation is becoming increasingly important for the efficient neuromodulation of both neurological and psychiatric disorders.
View Article and Find Full Text PDFDysphagia in multiple sclerosis: pathophysiology, assessment, and management-an overview.
Front Neurol
December 2024
Unit of Neurology, IRCCS Neuromed, Pozzilli, Italy.
Dysphagia is a frequent and life-threatening complication of multiple sclerosis (MS). Swallowing disturbances may be present at all stages of MS, although their prevalence increases with age, with disease duration, and in progressive phenotypes. The pathophysiology of dysphagia in MS is likely due to a combination of factors, including the involvement of corticobulbar tracts, the cerebellum, and the brainstem.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!