AI Article Synopsis
- The study aimed to measure soluble CD95 ligand (sCD95L) levels in patients with traumatic spinal cord injury over time.
- Blood samples were taken from 23 patients at various intervals post-injury to assess sCD95L using immunoassays.
- Findings showed a significant drop in sCD95L levels within the first 24 hours, followed by a rise, with levels at 8 and 12 weeks significantly exceeding those at admission, suggesting sCD95L might be a potential therapeutic target.
Article Abstract
Objective: To determine serum concentrations of soluble CD95 ligand (sCD95L) in patients with traumatic spinal cord injury.
Methods: Patients with traumatic spinal cord injury were recruited. Blood was collected on admission to hospital and at 4 h, 9 h, 12 h, 24 h, 3 days, 7 days, and 2, 4, 8 and 12 weeks postadmission. Serum concentrations of sCD95L were determined via immunoassay.
Result: The study included 23 patients. Mean sCD95L concentrations were significantly lower at 4 h, 9 h, 12 h and 24 h than at admission, and were significantly higher at 8 and 12 weeks, compared with admission.
Conclusion: The serum sCD95L concentration fell significantly during the first 24 h after traumatic spinal cord injury. Concentrations then rose, becoming significantly higher than admission levels at 8 weeks. sCD95L may represent a possible therapeutic target for traumatic spinal cord injury.
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| http://dx.doi.org/10.1177/0300060514559794 | DOI Listing |
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