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Intramuscular cobinamide versus saline for treatment of severe hydrogen sulfide toxicity in swine.
Clin Toxicol (Phila)
March 2019
b Department of Emergency Medicine , University of Colorado, School of Medicine, Aurora , CO , USA.
Introduction: Hydrogen sulfide (HS) is found in petroleum, natural gas, and decaying organic matter. Terrorist groups have attempted to use it in enclosed spaces as a chemical weapon. Mass casualty scenarios have occurred from industrial accidents and release from oil field sites.
View Article and Find Full Text PDFEfficacy of Intravenous Cobinamide Versus Hydroxocobalamin or Saline for Treatment of Severe Hydrogen Sulfide Toxicity in a Swine (Sus scrofa) Model.
Acad Emerg Med
September 2017
Department of Medicine, University of California at San Diego, La Jolla, CA.
Background: Hydrogen sulfide (H S) is a potentially deadly gas that naturally occurs in petroleum and natural gas. The Occupational Health and Safety Administration cites H S as a leading cause of workplace gas inhalation deaths. Mass casualties of H S toxicity may be caused by exposure from industrial accidents or release from oil field sites.
View Article and Find Full Text PDFNitrocobinamide, a new cyanide antidote that can be administered by intramuscular injection.
J Med Chem
February 2015
Departments of †Medicine, ‡Pathology, §Chemistry and Biochemistry, and ∥Anesthesiology, University of California-San Diego, La Jolla, California 92093-0652, United States.
Currently available cyanide antidotes must be given by intravenous injection over 5-10 min, making them ill-suited for treating many people in the field, as could occur in a major fire, an industrial accident, or a terrorist attack. These scenarios call for a drug that can be given quickly, e.g.
View Article and Find Full Text PDFIntravenous cobinamide versus hydroxocobalamin for acute treatment of severe cyanide poisoning in a swine (Sus scrofa) model.
Ann Emerg Med
December 2014
University of California, San Diego, San Diego, CA.
Study Objective: Hydroxocobalamin is a Food and Drug Administration-approved antidote for cyanide poisoning. Cobinamide is a potential antidote that contains 2 cyanide-binding sites. To our knowledge, no study has directly compared hydroxocobalamin with cobinamide in a severe, cyanide-toxic large-animal model.
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