In this overview, we highlight some recent advances in the interaction of natural and synthetic flavonoids with ionotropic GABA receptors. Examples of positive, negative, and neutralizing allosteric modulators as well as allosteric agonists are given. Flavonoids appear to act via multiple binding sites on GABA receptors. Unraveling these active sites remains a major task.
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| http://dx.doi.org/10.1016/bs.apha.2014.10.007 | DOI Listing |
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