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Review on the o-aminoaniline Moiety in Peptide and Protein Chemistry.
Chembiochem
January 2025
University of Wisconsin-Madison, Pharmacy, 777 Highland Ave, 53705, Madison, UNITED STATES OF AMERICA.
Peptides and proteins are important functional biomolecules both inside and outside of living organisms. The ability to prepare various types of functionalized peptides and proteins is essential for understanding fundamental biological processes, such as protein folding and post-translational modifications (PTMs), and for developing new therapeutics for many diseases, such as cancers and neurodegenerative diseases. The o-aminoaniline moiety was first proposed for activation to a thioester precursor and used for native chemical ligation to prepare large peptides and proteins.
View Article and Find Full Text PDFRegulatory and retrograde signaling networks in the chlorophyll biosynthetic pathway.
J Integr Plant Biol
January 2025
Key Laboratory of Photobiology, Institute of Botany, the Chinese Academy of Sciences, Beijing, 100093, China.
Plants, algae and photosynthetic bacteria convert light into chemical energy by means of photosynthesis, thus providing food and energy for most organisms on Earth. Photosynthetic pigments, including chlorophylls (Chls) and carotenoids, are essential components that absorb the light energy necessary to drive electron transport in photosynthesis. The biosynthesis of Chl shares several steps in common with the biosynthesis of other tetrapyrroles, including siroheme, heme and phycobilins.
View Article and Find Full Text PDFSocial, Racial, and Economic Disparities Affecting Outcomes of Hypertensive Adolescents.
J Clin Hypertens (Greenwich)
January 2025
Department of Pediatrics, Louisiana State University Health Sciences Center, New Orleans, USA.
Essential hypertension is one of the most common conditions managed in pediatric cardiology and can result in lasting deleterious effects on the cardiovascular system. Pediatric hypertension is so prevalent in the United States that it is often referred to as a public health challenge. Social determinants of health (SDH) are the cultural, economic, educational, healthcare accessibility, and political influences in the environment in which an individual is born or lives, all of which can affect that individual's overall health.
View Article and Find Full Text PDFEmpirical vitalism: observing an organism's formative power within an active and co-constitutive relation between subject and object.
Hist Philos Life Sci
January 2025
Akanthos Academy, Zur Uhlandshöhe 10, 70188, Stuttgart, Germany.
This article proposes an empirical approach to understanding the life of an organism that overcomes reductionist and dualist conceptions. The approach is based on Immanuel Kant's analysis of the cognitive conditions required for the recognition of an organism: the concept of teleology and the assumption of a formative power of self-generation. It is analyzed how these two criteria are applied in the cognition of a developing organism.
View Article and Find Full Text PDFFood-Induced Adverse Reactions: A Review of Physiological Food Quality Control, Mucosal Defense Mechanisms, and Gastrointestinal Physiology.
Toxics
January 2025
State Key Laboratory of Food Science and Resources, School of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
Although food is essential for the survival of organisms, it can also trigger a variety of adverse reactions, ranging from nutrient intolerances to celiac disease and food allergies. Food not only contains essential nutrients but also includes numerous substances that may have positive or negative effects on the consuming organism. To protect against potentially harmful components, all animals have evolved defense mechanisms, which are similar to antimicrobial defenses but often come at the cost of the organism's health.
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