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Temporary microaxial transvalvular left ventricular assist device for post-myocardial infarction ventricular septal rupture: Bridging a paradigm shift.
JTCVS Tech
December 2024
Department of Thoracic and Cardiovascular Surgery, Kaufman Center for Heart Failure Treatment and Recovery, Heart, Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, Ohio.
Objective: To characterize the clinical courses and outcomes of patients presenting with post-myocardial infarction (MI) ventricular septal rupture (VSR) receiving temporary microaxial transvalvular left ventricular assist device (tVAD) support.
Methods: Between December 2019 and July 2023, 10 consecutive patients presented with a post-MI VSR. All 10 patients received a tVAD.
Very old patients in the ICU in Latin America: A narrative review.
Rev Esp Geriatr Gerontol
October 2024
Geriatrics Unit, Hospital Clínico Universidad de Chile, Santiago, Chile; GERO, Centro Fondap de Gerosciencia y Metabolismo, Chile. Electronic address:
The population of very elderly patients (aged 80 years and older) in intensive care units (ICUs) is steadily growing. These patients have unique physiological, cognitive, functional, and social characteristics that affect their entire ICU course. Immobility, delirium, dysphagia, malnutrition, and polypharmacy are among the most common geriatric syndromes in these patients, and they contribute to a higher risk of acute and long-term functional decline and mortality.
View Article and Find Full Text PDFLiving systematic review and comprehensive network meta-analysis of ALS clinical trials: study protocol.
BMJ Open
November 2024
Department of Neurology, University Medical Center Utrecht, Utrecht, The Netherlands
Introduction: Amyotrophic lateral sclerosis (ALS) is a fatal neurogenerative disease with no effective treatment to date. Despite numerous clinical trials, the majority of studies have been futile in their effort to significantly alter the course of the disease. However, these studies may still provide valuable information for identifying patient subgroups and generating new hypotheses for future research.
View Article and Find Full Text PDFEnhanced thermal stability enables human mismatch-specific thymine-DNA glycosylase to catalyse futile DNA repair.
PLoS One
October 2024
Group «Mechanisms of DNA Repair and Carcinogenesis», CNRS UMR9019, Université Paris-Saclay, Gustave Roussy Cancer Campus, Villejuif Cedex, France.
Human thymine-DNA glycosylase (TDG) excises T mispaired with G in a CpG context to initiate the base excision repair (BER) pathway. TDG is also involved in epigenetic regulation of gene expression by participating in active DNA demethylation. Here we demonstrate that under extended incubation time the full-length TDG (TDGFL), but neither its isolated catalytic domain (TDGcat) nor methyl-CpG binding domain-containing protein 4 (MBD4) DNA glycosylase, exhibits significant excision activity towards T and C in regular non-damaged DNA duplex in TpG/CpA and CpG/CpG contexts.
View Article and Find Full Text PDFMortality Review Committee: Understanding Inpatient and 30-Day Mortality at a Comprehensive Cancer Center.
J Palliat Med
December 2024
Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA.
The Triple Aim of health care involves the simultaneous pursuit of improving the individual experience of care, population health, and reducing per capita costs of care. Our institution established a Mortality Review Committee (MRC) to review instances of inpatient mortality as part of continuing quality improvement with the goal of improving goal concordant care. In this article, we report the experience of MRC.
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