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The effect of intravenous hydromorphone alone or in combination with midazolam or dexmedetomidine on intraocular pressure in dogs.
Vet Anaesth Analg
January 2025
Department of Clinical Sciences, Cummings School of Veterinary Medicine at Tufts University, North Grafton, MA, USA.
Objective: To evaluate the effect of intravenous (IV) hydromorphone alone or in combination with midazolam or dexmedetomidine on intraocular pressure (IOP) in dogs.
Study Design: Prospective, randomized, blinded, crossover study.
Animals: A group of seven healthy, ophthalmologically normal, adult Beagle dogs.
Hydromorphone hydrochloride preconditioning combined with postconditioning attenuates myocardial ischemia/reperfusion injury in rats by improving mitochondrial function and activating the PI3K/Akt signaling pathway.
Chem Biol Drug Des
February 2024
Department of Anesthesiology, Huizhou Central People's Hospital, Huizhou, Guangdong, China.
Thrombolytic therapy or percutaneous coronary intervention for myocardial infarction often cause myocardial ischemia/reperfusion injury (MIRI) and poor prognosis of patients. This study aimed to explore the protective effect and potential mechanism of hydromorphone hydrochloride (HH) on MIRI. Fifty Sprague-Dawley male rats were randomly divided into Sham group, I/R group, HH-pre group, HH-post group, and HH-pre + post group.
View Article and Find Full Text PDFRelationship between opioid cross-tolerance during buprenorphine stabilization and return to opioid use during buprenorphine dose tapering.
Psychopharmacology (Berl)
June 2024
Wayne State University School of Medicine, Detroit, MI, USA.
Rationale: Opioid injection drug use (IDU) has been linked to a more severe pattern of use (e.g. tolerance, overdose risk) and shorter retention in treatment, which may undermine abstinence attempts.
View Article and Find Full Text PDFHYDROMORPHONE MITIGATES CARDIOPULMONARY BYPASS-INDUCED ACUTE LUNG INJURY BY REPRESSING PYROPTOSIS OF ALVEOLAR MACROPHAGES.
Shock
July 2023
Department of Anesthesiology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, China.
Introduction: Acute lung injury (ALI) is a devastating pulmonary illness with diffuse inflammatory responses. Hydromorphone (Hyd) is an opioid agonist used for relieving moderate-to-severe pain. The present work investigated the effect of Hyd on cardiopulmonary bypass (CPB)-induced ALI by regulating pyroptosis of alveolar macrophages (AMs).
View Article and Find Full Text PDFIntrathecal hydromorphone as an analgesia option for gynecology patients.
JAAPA
August 2020
Shilpa Gajarawala is an assistant professor of obstetrics and gynecology in the Mayo Clinic College of Medicine and Science and an adjunct faculty member in the doctor of medical science program at Rocky Mountain University of Health Professions in Provo, Utah. Ali Wells is a postdoctoral student at the University of South Florida College of Medicine in Tampa, Fla. Elyse Watkins is an associate professor in the DMSc program at the University of Lynchburg in Lynchburg, Va. Bartley Rust is program director of the DMSc program at Rocky Mountain University of Health Professions. Mark E. Archambault is an associate professor in the DMSc program at the University of Lynchburg. The authors have disclosed no potential conflicts of interest, financial or otherwise.
Enhanced recovery after surgery (ERAS) is a multimodal perioperative strategy originally developed to attenuate the postsurgical stress response in patients after colorectal surgery. Patients undergoing gynecologic surgery who had ERAS had significantly shorter hospital length of stay, reduced hospital-related costs, and acceptable pain management with reduced opioid use, without compromising patient satisfaction. Intrathecal hydromorphone is an effective alternative ERAS protocol analgesia for these patients and will not compromise patient outcomes or healthcare costs.
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