Climbing fiber receptive fields are a physiological marker that have proven useful to delineate the details of the olivocerebellar circuitry. They have also proven useful as a point of reference to delineate the organization of other parts of the cerebellar circuitry. But what does the location of the climbing fiber receptive field imply and what is its relation to the presumed role of the cerebellum in coordination? Can we expect that all climbing fibers have a peripheral receptive field on the skin? In this short review, we aim to cover these issues.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1007/s12311-015-0647-y | DOI Listing |
Physiol Behav
January 2025
Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address:
C1q/TNF-related protein 14 (CTRP14), also known as C1q-like 1 (C1QL1), is a synaptic protein predominantly expressed in the brain. It plays a critical role in the formation and maintenance of the climbing fiber-Purkinje cell synapses, ensuring that only one single winning climbing fiber from the inferior olivary neuron synapses with the proximal dendrites of Purkinje cells during the early postnatal period. Loss of CTRP14/C1QL1 results in incomplete elimination of supernumerary climbing fibers, leading to multiple persistent climbing fibers synapsing with the Purkinje cells.
View Article and Find Full Text PDFBMC Musculoskelet Disord
January 2025
Department of Orthopaedics and Traumatology, Faculty of Medicine, Dokuz Eylül University, İzmir, 35340, Turkey.
Background: Menisci, one of the most important anatomical structures of the knee joint, plays a role in load transfer, stability, shock absorption, prevention of articular cartilage degeneration, and proprioception. Type I collagen, the main component of the meniscus, and type II collagen fibers play an important role in the stability of the knee joint. This study aimed to evaluate the effects of Naturagen® 4 Joint product containing type I, II, and III collagen on pain, quality of life, and physical functions in patients with meniscopathy.
View Article and Find Full Text PDFInt J Sports Physiol Perform
December 2024
School of Sport Science, UiT The Arctic University of Norway, Tromsø, Norway.
Introduction: Women have generally lower body size and lean- to fat-mass ratio, lower maximal anaerobic power due to a lower muscle mass, and fewer fast-twitch fibers, although they can show higher resistance to fatigue or greater metabolic flexibility than men. These factors are well known and explain the sex differences in endurance sports such as distance running (10%-12%). Several of these factors-particularly the differences in body composition and skeletal-muscle characteristics-may directly impact vertical displacement and uphill performance.
View Article and Find Full Text PDFElife
December 2024
Université Paris Cité, CNRS, Saints-Pères Paris Institute for the Neurosciences, Paris, France.
Granule cells of the cerebellum make up to 175,000 excitatory synapses on a single Purkinje cell, encoding the wide variety of information from the mossy fibre inputs into the cerebellar cortex. The granule cell axon is made of an ascending portion and a long parallel fibre extending at right angles, an architecture suggesting that synapses formed by the two segments of the axon could encode different information. There are controversial indications that ascending axon (AA) and parallel fibre (PF) synapse properties and modalities of plasticity are different.
View Article and Find Full Text PDFAm J Bot
November 2024
Naturalis Biodiversity Center, Darwinweg 2, Leiden, 2333CR, The Netherlands.
Premise: This paper provides an overview of the wood anatomy of the dogbane family (Apocynaceae), reconstructs wood anatomical trait evolution, and links this evolution with woody growth-form transitions and floral and seed trait innovations across the family.
Methods: Over 200 published wood anatomical descriptions were revised, and original light microscopic sections were made and described for another 50 species. Changes in wood anatomical characters through time were visualized with ancestral state reconstructions.
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!