AI Article Synopsis
- A multifunctional nanocarrier has been developed to effectively encapsulate and deliver short interfering RNA (siRNA) using cationic fluorescent polymer core-shell nanoparticles.
- The nanocarrier shows better biocompatibility and higher transfection efficiency compared to the commonly used reagent, Lipofectamine 2000.
- It utilizes fluorescence resonance energy transfer to allow for non-invasive and label-free tracking of siRNA release within cells.
Article Abstract
A multifunctional nanocarrier for encapsulation and delivery of short interfering RNA (siRNA) has been realized using cationic fluorescent polymer core-shell nanoparticles. The nanocarrier has good biocompatibility and high transfection efficiency over the most popular transfection reagent, Lipofectamine 2000. Fluorescence resonance energy transfer within the nanocarrier provides a non-invasive and label-free method to track the intracellular release of siRNA.
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| http://dx.doi.org/10.1039/c4cc09685a | DOI Listing |
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