A fully 3D biomaterial containing overlapping gradations of structural, compositional, and biomolecular cues as seen in native orthopedic interfaces is described for the first time. A multi-compartment collagen scaffold is created for engineering tendon-bone junctions connected by a continuous interface that can induce spatially specific MSC differentiation down tenogenic and osteogenic lineages without the use of differentiation media.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4409544PMC
http://dx.doi.org/10.1002/adhm.201400809DOI Listing

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