Regulatory T (T) cells require PTEN to block PI3K signaling while maintaining Foxp3 expression. In the absence of PTEN, T cells lose Foxp3 expression and their suppressive function, leading to a systemic increase in interferon-γ secretion, with consequent expansion of pathogenic T helper 1 and follicular B helper T cells and systemic autoimmunity.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4447107 | PMC |
| http://dx.doi.org/10.1038/ni.3082 | DOI Listing |
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