AI Article Synopsis
- Microwave-assisted iminyl radical cyclizations can be halted by using TEMPO, leading to useful adducts.
- The process effectively utilizes alkynes to produce various 2-acylpyrroles with high yields.
- This method avoids the use of toxic reagents and simplifies the creation of O-phenyl oxime ether substrates from common ketones in just one step.
Article Abstract
Microwave-promoted iminyl radical cyclizations can be terminated by trapping with TEMPO, affording functionalized adducts. The use of alkynes as radical acceptors delivers a range of 2-acylpyrroles in good yields. Toxic and hazardous reagents, which are frequently employed in radical reactions, are not required. The O-phenyl oxime ether substrates are constructed in a single step from readily available ketones.
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| http://dx.doi.org/10.1021/ol5035047 | DOI Listing |
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