Bone morphogenetic proteins (BMPs) are secreted extracellular matrix (ECM)-associated proteins that regulate a wide range of developmental processes, including limb and kidney formation. A critical element of BMP regulation is the presence of secreted antagonists that bind and inhibit BMP binding to their cognate Ser/Thr kinase receptors at the plasma membrane. Antagonists such as Noggin, Chordin, Gremlin (Grem1), and twisted gastrulation-1 (Twsg1) have been shown to inhibit BMP action in a range of different cell types and developmental stage-specific contexts. Here we review new developments in the field of BMP and BMP antagonist biology during mammalian development and suggest strategies for targeting these proteins in human disease.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.tcb.2014.12.004 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Nlnemo suppresses of BMP signaling in wing development of the brown planthopper, Nilaparvata lugens.
Int J Biol Macromol
January 2025
Hubei Insect Resources Utilization and Sustainable Pest Management Key Laboratory, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, China. Electronic address:
Nemo-like kinases (NLKs) integrate multiple signaling pathways and exhibit functional diversity in developmental processes, including the bone morphogenetic protein (BMP) pathway. However, their roles in insect wing development, particularly in hemimetabolous insects like the brown planthopper (Nilaparvata lugens), remain poorly understood. Here, we investigated the role of Nlnemo (Nlnmo), an NLK, in the wing development of N.
View Article and Find Full Text PDFDual inhibition of MAPK/ERK and BMP signaling induces entorhinal-like identity in mouse ESC-derived pallial progenitors.
Stem Cell Reports
December 2024
Laboratorio di Biologia, Scuola Normale Superiore, 56126 Pisa, Italy; Istituto di Biofisica, Consiglio Nazionale delle Ricerche, 56124 Pisa, Italy. Electronic address:
The mechanisms that determine distinct embryonic pallial identities remain elusive. The central role of Wnt signaling in directing dorsal telencephalic progenitors to the isocortex or hippocampus has been elucidated. Here, we show that timely inhibition of MAPK/ERK and BMP signaling in neuralized mouse embryonic stem cells (ESCs) specifies a cell identity characteristic of the allocortex.
View Article and Find Full Text PDFTargeting BMP-1 enhances anti-tumoral effects of doxorubicin in metastatic mammary cancer: common and distinct features of TGF-β inhibition.
Breast Cancer Res Treat
January 2025
Department of Oncology, University of Torino, Via Nizza 44, 10126, Turin, Italy.
Article Synopsis
- Mammary carcinoma consists of different cell types with varying abilities to spread, and a specific type of cell (4T1) was identified as highly metastatic, influenced by TGF-β and BMP-1.
- Researchers found that inhibiting BMP-1 not only reduced cancer cell growth but also improved the effectiveness of the chemotherapy drug doxorubicin.
- This study highlights the potential of targeting BMP-1 as a promising therapeutic strategy for treating aggressive metastatic breast cancer.
A Recombinant Antibody Against ALK2 Promotes Tissue Iron Redistribution and Contributes to Anemia Resolution in a Mouse Model of Anemia of Inflammation.
Am J Hematol
January 2025
Keros Therapeutics, Lexington, Massachusetts, USA.
Patients with chronic inflammation are burdened with anemia of inflammation (AI), where inflammatory cytokines inhibit erythropoiesis, impede erythropoietin production, and limit iron availability by inducing the iron regulator hepcidin. High hepcidin hinders iron absorption and recycling, thereby worsening the impaired erythropoiesis by restricting iron availability. AI management is important as anemia impacts quality of life and potentially affects morbidity and mortality.
View Article and Find Full Text PDFNoggin Combined With Human Dental Pulp Stem Cells to Promote Skeletal Muscle Regeneration.
Stem Cells Int
December 2024
Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Shanghai Stomatological Hospital and School of Stomatology, Fudan University, Shanghai, China.
Article Synopsis
- Dental pulp stem cells (DPSCs) show promise for muscle injury repair, but their ability to differentiate into muscle cells is currently limited.
- Treating DPSCs with Noggin, which inhibits bone morphogenetic protein (BMP) signals, enhances myogenic differentiation, increases myogenic markers, and generates satellite-like cells, improving muscle regeneration.
- Implanting Noggin-treated DPSCs in a mouse model of muscle loss resulted in significant reductions in defect size and scar tissue, indicating that BMP/Smad signaling regulation by Noggin effectively promotes muscle repair.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!