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| http://dx.doi.org/10.1038/eye.2014.322 | DOI Listing |
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Systemic TRPV4 inhibition worsens retinal response to acute intraocular pressure elevation in older but not younger mice.
Optom Vis Sci
January 2025
Department of Anatomy and Physiology, The University of Melbourne, Parkville, Victoria, Australia.
Significance: Previous evidence showed that transient receptor potential vanilloid 4 (TRPV4) inhibition was protective of retinal ganglion cell (RGC) loss after chronic intraocular pressure (IOP) elevation in young animals. However, the role of TRPV4 in mechanosensing IOP changes in the aging eye is not well understood.
Purpose: This study compared the recovery of retinal function and structure after acute IOP elevation in 3- and 12-month-old mouse eyes with and without TRPV4 inhibition.
Oculomotor challenges in macular degeneration impact motion extrapolation.
J Vis
January 2025
Smith Kettlewell Eye Research Institute, San Francisco, CA, USA.
Macular degeneration (MD), which affects the central visual field including the fovea, has a profound impact on acuity and oculomotor control. We used a motion extrapolation task to investigate the contribution of various factors that potentially impact motion estimation, including the transient disappearance of the target into the scotoma, increased position uncertainty associated with eccentric target positions, and increased oculomotor noise due to the use of a non-foveal locus for fixation and for eye movements. Observers performed a perceptual baseball task where they judged whether the target would intersect or miss a rectangular region (the plate).
View Article and Find Full Text PDFAcute transient choroidal elevation induced by hyperpermeability of asymmetrical pachyvessel over-crossed watershed zone.
Am J Ophthalmol Case Rep
March 2025
Department of Ophthalmology, Asahikawa Medical University, Asahikawa, Japan.
Purpose: To describe a case of an elderly woman who presented with acute choroidal elevation, and the elevation disappeared without any treatment a month after the onset.
Observation: A 64-year-old woman presented to the clinic with complaint of blurred vision in her left eye. Her left visual acuity was 20/32 and choroidal elevation in the macular and subretinal fluid of the left eye was observed with optical coherence tomography (OCT), and no abnormalities in her right eye.
An analysis of heavy silicone oil treatment for inferior proliferative vitreoretinopathy.
BMC Ophthalmol
January 2025
Oxford Eye Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
Purpose: Proliferative vitreoretinopathy (PVR) is a complication of retinal detachment which requires multiple vitreoretinal surgical interventions and frequent use of oil endotamponade. In this study, we conducted an in-depth analysis of complications associated with the use of heavy silicone oil in the management of inferior PVR.
Methods: A retrospective cohort study of 20 eyes that underwent vitrectomy for inferior PVR with use of heavy silicone oil (Densiron 68) between March 2021 and October 2022 at Oxford Eye Hospital.
Acquired Dyschromatopsia and Its Link to Drug Toxicity.
Cureus
December 2024
Optometric - Glaucoma, Leicester Royal Infirmary, Leicester, GBR.
Colour vision defects (CVDs) can be both congenital and acquired, with acquired dyschromatopsia often associated with medication toxicity. This review explores various standardised colour vision tests used to detect these defects, including the Ishihara plate test, Farnsworth-Munsell 100 hue test, and anomaloscopes. These methods are evaluated for their effectiveness in diagnosing CVDs, particularly in acquired conditions.
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