Out of a series of 364 patients, 56 cases of essential trigeminal neuralgias operated upon by retrogasserian radicotomy by intradural temporal route are presented. Pointing out that we are in a period of confrontation between the great surgery, classical or micro-neurosurgery of the trigeminal nerve and the drug therapy or percutaneous surgery, the authors conclude that the indication of great surgery is restricted but has not disappeared--taking into account the good permanent results obtained (89%) and the reduced rate of failures and recurrences (11%). In the conditions of a general anesthesia with intracranial hypotension and correct surveillance the surgeon has gaine an extra security when performing these operations.
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IUBMB Life
January 2025
Cheerland Watson Precision Medicine Ltd, Shenzhen, China.
Parkinson's disease (PD), characterized by progressive degeneration of dopaminergic neurons in substantia nigra, has no disease-modifying therapy. Mesenchymal stem cell (MSC) therapy has shown great promise as a disease-modifying solution for PD. Induced pluripotent stem cell-derived MSC (iMSC) not only has stronger neural repair function, but also helps solve the problem of MSC heterogeneity.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
January 2025
State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200032, China.
Ferroptosis, a unique form of iron-dependent cell death triggered by lipid peroxidation accumulation, holds great promise for cancer therapy. Despite the crucial role of GPX4 in regulating ferroptosis, our understanding of GPX4 protein regulation remains limited. Through FACS-based genome-wide CRISPR screening, we identified MALT1 as a regulator of GPX4 protein.
View Article and Find Full Text PDFMymensingh Med J
January 2025
Dr Hitha Antony, Post Graduation 3rd Year Student, Department of Physiology, All India Institute Of Medical Science (AIIMS), Bhopal, India; E-mail:
To assess and compare the sensory component of the saphenous nerve in Coronary artery disease (CAD) patients undergoing Coronary artery bypass graft (CABG) with great saphenous vein graft pre and post-CABG. An observational longitudinal study evaluating the effect of surgery on the saphenous nerve involved 32 CAD patients undergoing CABG. This study was carried out jointly by the Department of Physiology and the Department of Cardiothoracic Vascular Surgery (CTVS) at All India Institute of Medical Sciences, Bhopal, India from November 2022 to January 2024.
View Article and Find Full Text PDFJ Ophthalmic Inflamm Infect
December 2024
Shroff Eye Center, Kailash Colony, New Delhi, India.
Purpose: To report a case of bilateral primary vitreoretinal lymphoma (PVRL) masquerading as endophthalmitis in a patient with a history of bilateral cataract surgery and COVID-19.
Observation: A 60-year-old male patient presented with diminution of vision in both the eyes. There was a history of bilateral cataract surgery done 2 months back at a gap of one week and COVID-19 infection treated with high dose systemic corticosteroids.
J Robot Surg
December 2024
National Engineering Research Center of Neuromodulation, School of Aerospace Engineering, Tsinghua University, Beijing, 100084, China.
Magnetic resonance imaging (MRI) offers high-quality soft tissue imaging without radiation exposure, which allows stereotactic techniques to significantly improve outcomes in cranial surgeries, particularly in deep brain stimulation (DBS) procedures. However, conventional stereotactic neurosurgeries often rely on mechanical stereotactic head frames and preoperative imaging, leading to suboptimal results due to the invisibility and the contact with patient's head, which may cause additional harm. This paper presents a frameless, MRI-guided stereotactic neurosurgical robotic system.
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