AI Article Synopsis
- The study addresses limitations of tough hydrogels as biomaterials, focusing on issues like fabrication difficulties, toxic materials, and performance under stress.
- The authors introduce a one-step technique that combines two chemical reactions to create robust hydrogels with impressive compressive strength and no deformation issues.
- The resulting hydrogels can be easily modified after formation and can quickly gel under body-like conditions to safely encapsulate human cells.
Article Abstract
The use of tough hydrogels as biomaterials is limited as a consequence of time-consuming fabrication techniques, toxic starting materials, and large strain hysteresis under deformation. Herein, we report the simultaneous application of nucleophilic thiol-yne and inverse electron-demand Diels-Alder additions to independently create two interpenetrating networks in a simple one-step procedure. The resultant hydrogels display compressive stresses of 14-15 MPa at 98% compression without fracture or hysteresis upon repeated load. The hydrogel networks can be spatially and temporally postfunctionalized via radical thiylation and/or inverse electron-demand Diels-Alder addition to residual functional groups within the network. Furthermore, gelation occurs rapidly under physiological conditions, enabling encapsulation of human cells.
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| http://dx.doi.org/10.1021/ja511681s | DOI Listing |
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