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Anti-melanogenic effects of hydroxyethyl chrysin through the inhibition of tyrosinase activity: and approaches.
Heliyon
January 2025
Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup, 56212, Republic of Korea.
The suppression of tyrosinase (TYR), a key enzyme in melanogenesis, has been suggested as an effective strategy for preventing melanin accumulation. We previously discovered the novel chrysin derivative hydroxyethyl chrysin (HE-chrysin) through an irradiation technique, which exerted higher anti-inflammatory and anti-cancer activities than original chrysin. In the present study, we explored whether HE-chrysin has antioxidant and anti-melanogenic capacity using B16F10 murine melanoma cells and molecular docking.
View Article and Find Full Text PDFClinical Evaluation of Faricimab in Real-World Diabetic Macular Edema in India- A Multicenter Observational Study.
Clin Ophthalmol
January 2025
Nethralayam Superspeciality Eye Care, Kolkata, India.
Purpose: To evaluate the efficacy of faricimab in real-world clinical settings in India for treating diabetic macular edema (DME) in treatment-naïve and recalcitrant eyes.
Patients And Methods: This retrospective study involved 39 eyes (16 treatment-naive and 23 recalcitrant) treated with intravitreal faricimab at four centers in India. Patients received three monthly loading doses followed by a pro-re-nata regimen, with outcomes measured for best-corrected visual acuity (BCVA), central macular thickness (CMT), intraretinal fluid (IRF), subretinal fluid (SRF), and hyperreflective foci (HRF).
SineKAN: Kolmogorov-Arnold Networks using sinusoidal activation functions.
Front Artif Intell
January 2025
Department of Physics and Astronomy, The University of Alabama, Tuscaloosa, AL, United States.
Recent work has established an alternative to traditional multi-layer perceptron neural networks in the form of Kolmogorov-Arnold Networks (KAN). The general KAN framework uses learnable activation functions on the edges of the computational graph followed by summation on nodes. The learnable edge activation functions in the original implementation are basis spline functions (B-Spline).
View Article and Find Full Text PDFMaslinic acid improves mitochondrial function and inhibits oxidative stress and autophagy in human gastric smooth muscle cells.
Open Life Sci
January 2025
Department of Pediatrics, Fujian Provincial Hospital, Shengli Clinical Medical College of Fujian Medical University, No. 134 Dong Street, Fuzhou, Fujian, 350001, China.
Functional dyspepsia (FD) is a chronic disease that occurs in the gastroduodenal region and significantly impacts human health. Maslinic acid (MA), a pentacyclic triterpene acid, is the primary bioactive ingredient in Chinese medicinal herbs such as hawthorn, which exhibits beneficial impacts on the regulation of various disease progressions. However, the specific functions and associated pathways of MA in FD progression remain unclear and require further investigation.
View Article and Find Full Text PDFA comprehensive study of the ground vibrational state of the C-13 substituted methanol using high-resolution Synchrotron radiation spectra: Perturbation, forbidden, torsional fundamental overtone, excited overtones, and hot overtones transitions.
Spectrochim Acta A Mol Biomol Spectrosc
December 2024
Department of Physics and Engineering, Albany State University, GA 31707. USA. Electronic address:
This work represents a comprehensive study of the ground vibrational state of C-13 substituted methanol using very high-resolution far-infrared (FIR) and infrared (IR) Synchrotron Radiation spectra recorded with a very high signal-to-noise (S/N) ratio in the entire region from 40to5000cm, at the Canadian Light sources. High resolution combined with a high S/N ratio allowed the recording to be done with an unprecedented resolution of about 0.0017cm.
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