A major challenge in nanofabrication is to pattern unconventional substrates that cannot be processed for a variety of reasons, such as incompatibility with spin coating, electron beam lithography, optical lithography, or wet chemical steps. Here, we present a versatile nanofabrication method based on re-usable silicon membrane hard masks, patterned using standard lithography and mature silicon processing technology. These masks, transferred precisely onto targeted regions, can be in the millimetre scale. They allow for fabrication on a wide range of substrates, including rough, soft, and non-conductive materials, enabling feature linewidths down to 10 nm. Plasma etching, lift-off, and ion implantation are realized without the need for scanning electron/ion beam processing, UV exposure, or wet etching on target substrates.
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http://dx.doi.org/10.1038/srep07802 | DOI Listing |
Antibiotics (Basel)
December 2024
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, Moscow 117997, Russia.
Irumamycin (Iru) is a complex polyketide with pronounced antifungal activity produced by a type I polyketide (PKS) synthase. Iru features a unique hemiketal ring and an epoxide group, making its biosynthesis and the structural diversity of related compounds particularly intriguing. In this study, we performed a detailed analysis of the biosynthetic gene cluster (BGC) to uncover the mechanisms underlying Iru formation.
View Article and Find Full Text PDFACS Omega
December 2024
Unconventional Computing Laboratory, University of the West of England, Bristol BS16 1QY, U.K.
We introduce a new abiotic-protein-based substrate for identifying English alphabet characters optically using proteinoids. Proteinoids, which are amino acid polymers produced under thermal stress conditions, have demonstrated promise as materials that are compatible with living organisms and can be used in a wide range of applications. We explore the potential of using proteinoids for the optical stimulation and detection of English alphabet characters.
View Article and Find Full Text PDFProtein Pept Lett
December 2024
Department of Biotechnology, Jaypee Institute of Information Technology, A-10 Sec 62, Noida, 201309, India.
Endogenous or exogenous DNA damage needs to be repaired, therefore, cells in all the three domains have repair pathways to maintain the integrity of their genetic material. Uracil DNA glycosylases (UDGs), also known as UNGs (uracil-DNA N-glycosylases), are part of the base-excision repair (BER) pathway. These enzymes specifically remove uracil from DNA molecules by cleaving the glycosidic bond between the uracil base and the deoxyribose sugar.
View Article and Find Full Text PDFFront Neurosci
December 2024
CIMAINA and Dipartimento di Fisica "A. Pontremoli", Università degli Studi di Milano, Milan, Italy.
The brain's ability to perform efficient and fault-tolerant data processing is strongly related to its peculiar interconnected adaptive architecture, based on redundant neural circuits interacting at different scales. By emulating the brain's processing and learning mechanisms, computing technologies strive to achieve higher levels of energy efficiency and computational performance. Although efforts to address neuromorphic solutions through hardware based on top-down CMOS-based technologies have obtained interesting results in terms of energetic efficiency improvement, the replication of brain's self-assembled and redundant architectures is not considered in the roadmaps of data processing electronics.
View Article and Find Full Text PDFChem Sci
December 2024
Department of Chemistry & Biochemistry, Department of Materials Science & Engineering, California NanoSystems Institute, University of California, Los Angeles Los Angeles CA 90095 USA
Laser-induced graphene (LIG) has gained significant attention, with over 170 publications in 2023 alone. This surge in popularity is due to the unique advantages LIG offers over traditional thermal methods, such as fast, solvent-free, scalable production and its ability to scribe intricate patterns on various substrates, including heat-sensitive materials like plastics. In recent developments, metal-embedded LIG (M-LIG) has expanded the potential applications of LIG, particularly in energy storage, microelectronics, and sensing.
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