Background: In this paper, we modify our previously developed conjoint tumor-normal cell model in order to make a distinction between tumor cells that are responsive to chemotherapy and those that may show resistance.
Results: Using this newly developed core model, the evolution of three cell types: normal, tumor, and drug-resistant tumor cells, is studied through a series of numerical simulations. In addition, we illustrate critical factors that cause different dynamical patterns for normal and tumor cells. Among these factors are the co-dependency of the normal and tumor cells, the cells' response mechanism to a single or multiple chemotherapeutic treatment, the drug administration sequence, and the treatment starting time.
Conclusion: The results provide us with a deeper understanding of the possible evolution of normal, drug-responsive, and drug-resistant tumor cells during the cancer progression, which may contribute to improving the therapeutic strategies.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4429337 | PMC |
| http://dx.doi.org/10.1186/1742-4682-12-3 | DOI Listing |
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