Natural product discovery arises through a unique interplay between chromatographic purification and biological assays. Currently, most techniques used for natural product purification deliver leads without a defined biological action. We now describe a technique, referred to herein as functional chromatography, that deploys biological affinity as the matrix for compound isolation.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4576851PMC
http://dx.doi.org/10.1039/c4ob02292kDOI Listing

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