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as an oral bacteria promotes the carcinogenesis of laryngeal cancer via upregulating YWHAZ.
J Oral Microbiol
December 2024
School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Background And Purpose: F. nucleatum, a gram-negative oral bacteria, is abundant in laryngeal cancer (LC). While specific 14-3-3 proteins act as LC oncogenes, the link between F.
View Article and Find Full Text PDFHistopathological study of the localization/distribution of Fusobacterium nucleatum in esophageal cancer.
Pathol Int
January 2025
Department of Pathology, Tohoku University Hospital, Sendai, Japan.
Fusobacterium nucleatum is implicated in esophageal cancer; however, its distribution in esophageal cancer tissues remains unknown. This study aimed to clarify the presence and distribution of F. nucleatum in esophageal cancer tissues using fluorescence in situ hybridization (FISH).
View Article and Find Full Text PDFFusobacterium nucleatum promotes colorectal cancer liver metastasis via miR-5692a/IL-8 axis by inducing epithelial-mesenchymal transition.
J Biomed Sci
January 2025
Department of Oncology, Tongji Hospital,Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Background: The association between the intestinal microbiota and colorectal cancer (CRC) has been extensively studied, with Fusobacterium nucleatum (F. nucleatum, FN) being found in high abundance in colorectal cancer tissues. Previous research has emphasized the significant role of F.
View Article and Find Full Text PDFProfiling lateral gene transfer events in the human microbiome using WAAFLE.
Nat Microbiol
January 2025
Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Lateral gene transfer (LGT), also known as horizontal gene transfer, facilitates genomic diversification in microbial populations. While previous work has surveyed LGT in human-associated microbial isolate genomes, the landscape of LGT arising in personal microbiomes is not well understood, as there are no widely adopted methods to characterize LGT from complex communities. Here we developed, benchmarked and validated a computational algorithm (WAAFLE or Workflow to Annotate Assemblies and Find LGT Events) to profile LGT from assembled metagenomes.
View Article and Find Full Text PDFDysregulated genes in HIGK-treated and their possible association with HNSCC.
Mol Biol Res Commun
January 2025
Clinical Genetics Lab, Centre for Cellular and Molecular Research, Saveetha Dental College & Hospital, Saveetha Institute of Medical and Technical Sciences [SIMATS], Saveetha University, Chennai, India.
The present study aims to identify the differentially expressed genes in HIGK treated with and their possible role in establishing head and neck squamous cell carcinoma. The study design follows a computational approach wherein multiple databases and tools are used to derive the possible association between exposure and the development of HNSCC. The GEOmnibus dataset GSE6927 provided data on the differentially expressed genes in the HIGK treated with .
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