Expanding the toolbox of asymmetric organocatalysis by continuous-flow process.

Chem Commun (Camb)

Institute of Natural Products Research, Center of Health Sciences, Federal University of Rio de Janeiro, CEP 21941902, Brazil.

Published: March 2015

AI Article Synopsis

  • The review highlights that while many organic chemistry techniques for continuous-flow processes exist, asymmetric synthesis has not been as widely explored.
  • It notes that organocatalysis has become a significant development in asymmetric catalysis since the foundational work of Barbas and MacMillan.
  • The article surveys existing research on the application of organocatalysis in continuous-flow setups, providing insights into its potential and effectiveness.

Article Abstract

Despite all the organic chemistry reaction methodologies already developed for the continuous-flow process, asymmetric synthesis is one that has gained less attention. Since the pioneering work of Barbas and MacMillan, organocatalysis has emerged as the third pillar of asymmetric catalysis. In this review, we present a survey of literature regarding the use of organocatalysis under continuous-flow conditions.

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Source
http://dx.doi.org/10.1039/c4cc08748hDOI Listing

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