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Sporadic inclusion body myositis: A review of recent clinical advances and current approaches to diagnosis and treatment.
Clin Neurophysiol
March 2016
Institute for Immunology and Infectious Diseases, Murdoch University, Western Australia, Australia.
Sporadic inclusion body myositis is the most frequent acquired myopathy of middle and later life and is distinguished from other inflammatory myopathies by its selective pattern of muscle involvement and slowly progressive course, and by the combination of inflammatory and degenerative muscle pathology and multi-protein deposits in muscle tissue. This review summarises the findings of recent studies that provide a more complete picture of the clinical phenotype and natural history of the disease and its global prevalence and genetic predisposition. Current diagnostic criteria, including the role of electrophysiological and muscle imaging studies and the recently identified anti-5'-nucleotidase (anti-cN1A) antibody in diagnosis are also discussed as well as current trends in the treatment of the disease.
View Article and Find Full Text PDFImmunocytochemical localization of ecto-5'-nucleotidase in cultures of cerebellar granule cells.
Neuroscience
January 1996
Biozentrum der J. W. Goethe-Universität, Frankfurt, Germany.
The distribution of ecto-5'-nucleotidase, a glycosyl phosphatidylinositol anchored membrane protein capable of hydrolysing extracellular nucleoside monophosphates, was investigated by immunocytochemistry in cultures of rat cerebellar cells obtained at postnatal days 6 and 8. The enzyme was expressed at the surface of granule cells including their neurites as well as on other neurons in the culture. The distribution of 5'-nucleotidase matched that of the synaptic vesicle protein 2.
View Article and Find Full Text PDFFunctional characterization of ecto-5'-nucleotidase-positive and -negative human T lymphocytes.
J Immunol
March 1989
Department of Immunology, Research Institute of Scripps Clinic, La Jolla, California 92037.
Functional studies were performed on human peripheral blood T lymphocytes stained with goat anti-5'-nucleotidase antibodies and separated into ecto-5'-nucleotidase (ecto-5'-NT)-positive and -negative populations using the FACSTAR fluorescence-activated cell sorter. On the average, ecto-5'-NT+ T cells contained 34 +/- 13% CD4+ and 55 +/- 15% CD8+ cells, whereas ecto-5'-NT-T cells contained 65 +/- 12% CD4+ and 23 +/- 8% CD8+ cells. Staining with anti-5'-NT antibodies did not significantly alter the ability of unseparated T cells to proliferate in response to PHA or PMA, or in a MLR.
View Article and Find Full Text PDFAnti-5'-nucleotidase antibodies cause human peripheral blood T cells to proliferate.
Adv Exp Med Biol
February 1990
Department of Immunology, Scripps Clinic and Research Foundation, La Jolla, CA.
Differences in the release of 5'-nucleotidase and alkaline phosphatase from plasma membrane of several cell types by PI-PLC.
Comp Biochem Physiol B
September 1989
Université de Nantes, C.H.R.U-Hôtel Dieu, Laboratoire de Biochimie Médicale, France.
1. We have compared the effect of phosphatidyl inositol specific phospholipase C (PI-PLC) on the attachment of both 5'-nucleotidase and alkaline phosphatase to the liver plasma membrane from different species. 2.
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