A kinetic template-guided tethering (KTGT) strategy has been developed for the site-directed discovery of fragments that bind to defined protein surfaces, where acrylamide-modified fragments can be irreversibly captured in a protein-templated conjugate addition reaction. Herein, an efficient and facile method is reported for the preparation of acrylamide libraries from a diverse range of amine fragments using a solid-supported quaternary amine base.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/ol503486t | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Lignin alkali regulated interfacial polymerization towards ultra-selective and highly permeable nanofiltration membrane.
Nat Commun
January 2025
School of Environmental Science and Engineering, Sun Yat-sen University, Guangzhou, China.
Thin-film composite polyamide (TFC PA) membranes hold promise for energy-efficient liquid separation, but achieving high permeance and precise separation membrane via a facile approach that is compatible with present manufacturing line remains a great challenge. Herein, we demonstrate the use of lignin alkali (LA) derived from waste of paper pulp as an aqueous phase additive to regulate interfacial polymerization (IP) process for achieving high performance nanofiltration (NF) membrane. Various characterizations and molecular dynamics simulations revealed that LA can promote the diffusion and partition of aqueous phase monomer piperazine (PIP) molecules into organic phase and their uniform dispersion on substrate, accelerating the IP reaction and promoting greater interfacial instabilities, thus endowing formation of TFC NF membrane with an ultrathin, highly cross-linked, and crumpled PA layer.
View Article and Find Full Text PDFLarge-area radiation-modulated thermoelectric fabrics for high-performance thermal management and electricity generation.
Sci Adv
January 2025
National Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, Suzhou, Jiangsu 215123, China.
Flexible thermoelectric systems capable of converting human body heat or solar heat into sustainable electricity are crucial for the development of self-powered wearable electronics. However, challenges persist in maintaining a stable temperature gradient and enabling scalable fabrication for their commercialization. Herein, we present a facile approach involving the screen printing of large-scale carbon nanotube (CNT)-based thermoelectric arrays on conventional textile.
View Article and Find Full Text PDFFlexible Passive Wireless Sensing Platform with Frequency Mapping and Multimodal Fusion.
ACS Appl Mater Interfaces
January 2025
Key Laboratory of MEMS of the Ministry of Education, Southeast University, Nanjing 210096, China.
As one of the core parts of the Internet-of-things (IOTs), multimodal sensors have exhibited great advantages in fields such as human-machine interaction, electronic skin, and environmental monitoring. However, current multimodal sensors substantially introduce a bloated equipment architecture and a complicated decoupling mechanism. In this work we propose a multimodal fusion sensing platform based on a power-dependent piecewise linear decoupling mechanism, allowing four parameters to be perceived and decoded from the passive wireless single component, which greatly broadens the configurable freedom of a sensor in the IOT.
View Article and Find Full Text PDFPhotoredox radical/polar crossover enables carbo-heterofunctionalization of alkenes: facile access to 1,3-difunctionalized nitro compounds.
Chem Commun (Camb)
January 2025
Department of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Freiestrasse 3, 3012 Bern, Switzerland.
Herein, we present an efficient and practical method for multicomponent carbo-heterofunctionalization of alkenes radical-polar crossover photoredox catalysis. Employing geminal bromonitroalkanes as redox-active reagents with a wide range of O-centered nucleophiles allows rapid access to various 1,3-difunctionalized nitro compounds, including β-nitro ketones, 1,3-nitro alcohols, 1,3-nitro ethers as well as cyclic molecules.
View Article and Find Full Text PDFSpontaneous bifacial capping of perovskite film for efficient and mechanically stable flexible solar cell.
Nat Commun
January 2025
The Institute of Technological Sciences, Wuhan University, Wuhan, China.
Flexible perovskite solar cells (F-PSCs) are appealing for their flexibility and high power-to-weight ratios. However, the fragile grain boundaries (GBs) in perovskite films can lead to stress and strain cracks under bending conditions, limiting the performance and stability of F-PSCs. Herein, we show that the perovskite film can facilely achieve in situ bifacial capping via introducing 4-(methoxy)benzylamine hydrobromide (MeOBABr) as the precursor additive.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!