A new dibenzocyclooctadiene lignan, renchangianin E (1) was isolated from the stems of Kadsura renchangiana. Its structure and stereochemistry were elucidated by spectroscopic methods, including 2D-NMR techniques.
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Am J Chin Med
January 2025
Department of Emergency and Critical Care Medicine, Wuxi 9th People's Hospital, Affiliated to Soochow University, Wuxi, Jiangsu 214000, P. R. China.
Hemorrhagic shock (HS) is a critical condition with high mortality caused by acute blood loss. Cardiac injury and dysfunction induced by HS is a major factor associated with the poor prognosis of affected patients. Schisandrin A (Sch A), a dibenzocyclooctadiene lignan extracted from , exhibits multiple biological activities, including anti-inflammatory, and antioxidant effects.
View Article and Find Full Text PDFFitoterapia
October 2024
School of Pharmaceutical Sciences, Hunan University of Medicine, Huaihua 418000, China; School of Pharmaceutical Science, University of South China, Hengyang 421001, Hunan Province, China. Electronic address:
The phytochemical investigations on the fruits of Kadsura coccinea led to the isolation of six undescribed dibenzocyclooctadiene lignans named kadcolignans B-G, together with eleven previously described analogues. The structures of these compounds were established by spectroscopic methods including NMR, HRESIMS, and CD experiments. All isolated compounds were evaluated for their hepatoprotective activity by measuring the levels of triglyceride (TG), total cholesterol (TC), and reactive oxygen species (ROS) in FFA-induced HepG2 cells.
View Article and Find Full Text PDFBiomed Pharmacother
August 2024
Drug Research Program, Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, Helsinki 00014, Finland. Electronic address:
The fading efficacy of antibiotics is a growing global health concern due to its life-threatening consequences and increased healthcare costs. Non-genetic mechanisms of antimicrobial resistance, such as those employed by Chlamydia pneumoniae and Chlamydia trachomatis, complicate treatment as these bacteria can enter a non-replicative, persistent state under stress, evading antibiotics and linking to inflammatory conditions. Understanding chlamydial persistence at the molecular level is challenging, and new models for studying Chlamydia-host interactions in vivo are urgently needed.
View Article and Find Full Text PDFInt J Mol Sci
March 2024
Department of Molecular Pharmacy, Faculty of Pharmacy, Masaryk University, 61200 Brno, Czech Republic.
(Schisandraceae) is a medicinal plant widely used in traditional Chinese medicine. Under the name Wu Wei Zi, it is used to treat many diseases, especially as a stimulant, adaptogen, and hepatoprotective. Dibenzocyclooctadiene lignans are the main compounds responsible for the effect of .
View Article and Find Full Text PDFChem Biodivers
September 2023
Vietnam Military Medical University, Hanoi, 100000, Vietnam.
A chemical investigation of K. heteroclite led to isolation of two new dibenzocyclooctadienes (1 and 2) together with 14 known compounds (3-16) by using multiple chromatographic techniques. New compounds (1 and 2) were obtained and identified by spectroscopic methods (HR-ESI-MS, 1D and 2D NMR, and ECD) as well as by comparison of their experimental data with those reported in the literatures.
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