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Highlights from the plenary session: cellular and molecular mechanisms of disease (I).
Rheumatology (Oxford)
March 2025
Vasculitis Expertise Center, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
In this plenary session of the Vasculitis Workshop 2024, pioneering translational research on autoimmune vasculitis, particularly ANCA-associated vasculitis (AAV), was presented, highlighting advancements in our understanding of disease mechanisms and promising therapeutic prospects. Advances in elucidating molecular pathways, such as IL-17 and IFN-I, pave the way for specific treatments. Preclinical studies have revealed the gut microbiome's role in the pathogenesis of MPO-AAV and demonstrate the therapeutic potential of dietary interventions.
View Article and Find Full Text PDFPioneering Clinical Investigation: Beta Defensin Expression in Patients of Squamous Cell Carcinoma of Oral Cavity as a Forward-Looking Validation for Molecular Treatment.
Indian J Otolaryngol Head Neck Surg
January 2025
Department of Otorhinolaryngology, All India Institute of Medical Sciences Jodhpur, Jodhpur, Rajasthan 342005 India.
Human defensins are peptides coded by certain genes released as a part of immune response that act differently to tumorigenic cells according to the class. A varied cellular response has been documented in the world literature concerning the role of defensins in the cancer cell lines, though the exact role in the internal human milieu and the role specific to head and neck cancers is still understudied. This study explores the possible role of Human Beta Defensin (HBD) 1 and 3 in head and neck squamous cell carcinoma in disease progression and their potential as biomarkers/prognostic markers.
View Article and Find Full Text PDFProceedings of the 12th annual deep brain stimulation think tank: cutting edge technology meets novel applications.
Front Hum Neurosci
February 2025
Norman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, United States.
The Deep Brain Stimulation (DBS) Think Tank XII was held on August 21st to 23rd. This year we showcased groundbreaking advancements in neuromodulation technology, focusing heavily on the novel uses of existing technology as well as next-generation technology. Our keynote speaker shared the vision of using neuro artificial intelligence to predict depression using brain electrophysiology.
View Article and Find Full Text PDFA formal statechart model of immediate neonatal adaptation guidelines.
Heliyon
February 2025
Universidad Nacional de Colombia, Sede Bogotá, Facultad de Medicina, Departamento de Pediatría, Bogotá, Colombia.
Research highlights the importance of applying physiological criteria for optimal umbilical cord clamping, underlining its lasting advantages. In response, the Division of Pediatrics, Perinatology, and Neonatology at the National University of Colombia has pioneered the Immediate Neonatal Adaptation Guideline, focusing on Physiologically-based Cord Clamping. This study has two main objectives: The first is to represent the medical guideline through a statechart model to enhance clarity and detail.
View Article and Find Full Text PDFSystemic effect of sympathectomy in the treatment of localized hyperhidrosis.
Updates Surg
March 2025
Department of Thoracic Surgery, Ankara Etlik City Hospital, Ankara, Turkey.
Hyperhidrosis is thought to result from excessive stimulation of sweat glands due to increased sympathetic activity; however, data on systemic responses following bilateral thoracic sympathectomy as the definitive treatment have not yet been sufficiently evaluated. This study, designed as a prospective cohort investigation, included 24 patients who underwent sympathectomy for palmar and axillary hyperhidrosis at our center in 2023, along with an age-matched control group of equal size. In the sympathectomy group, pupillometry measurements were performed 1 day before surgery and on the 7th postoperative day, while the control group underwent measurements at corresponding intervals.
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