Purpose: To investigate promoter methylation in the deleted in lung and esophageal cancer 1 (DLEC1) gene in Chinese patients with gastric cancer.
Methods: A total of 227 patients with gastric cancer were enrolled. The methylations of the promoter regions of DLEC1 and ACTB were determined using quantitative methylation-specific PCR. The DLEC1 methylation was compared to the clinicopathological variables of gastric cancer.
Results: DLEC1 methylation was not associated with the clinicopathological variables of gastric cancer. Patients with DLEC1-hypermethylated gastric cancer had significantly higher recurrence rate than those with DLEC1-hypomethylated gastric cancer (P = 0.025; hazard ratio = 2.43).
Conclusions: Methylation of DELC1 promoter may be a valuable predictor for recurrence in Chinese patients with gastric cancer.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4276360 | PMC |
| http://dx.doi.org/10.1155/2014/804023 | DOI Listing |
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