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Objectives Granulocyte colony-stimulating factor (G-CSF) is commonly used to accelerate neutrophil recovery after allogeneic stem cell transplantation (ASCT) in most transplant centers. There was no consensus on the optimal use of G-CSF after ASCT. Although we use G-CSF to minimize morbidity and mortality, G-CSF can increase the risk of graft-versus-host disease (GVHD).
View Article and Find Full Text PDFHyperacute Graft-Versus-Host Disease of the Skin following Allogeneic Stem Cell Transplantation: A Paediatric Case Series.
Indian J Dermatol
January 2023
Department of Dermatology, Christian Medical College, Vellore, Tamil Nadu, India.
Hyperacute GVHD (HaGVHD) is a rare complication of hematopoietic stem cell transplantation (HSCT) occurring before engraftment, a syndrome commonly involving skin and/or gut and/or liver, with increased morbidity and mortality. Myeloablative conditioning (MAC) regimes and mismatched donor transplants have an increased risk for HaGVHD. There is a higher chance of steroid-refractoriness and chronic GVHD in those who develop HaGVHD.
View Article and Find Full Text PDFThe First Reported Case of Allogenic Hematopoietic Stem Cell Transplantation for CML Blast Phase (Monocytic Lineage) in the Tyrosine Kinase Inhibitor Era.
Case Rep Oncol
May 2022
Department of Hematology, Toyama Prefectural Central Hospital, Toyama, Japan.
Chronic myeloid leukemia (CML) blast phase (monocytic lineage) is extremely rare. A 39-year-old Japanese man was diagnosed with CML blast phase (monocytic lineage). T315I mutation was positive, ponatinib was initially started, and then, allogenic hematopoietic stem cell transplantation (allo-HSCT) was performed.
View Article and Find Full Text PDFCheckpoint Inhibitors and the Changing Face of the Relapsed/Refractory Classical Hodgkin Lymphoma Pathway.
Curr Oncol Rep
November 2022
Department of Clinical Haematology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
Purpose Of Review: Checkpoint inhibitors (CPIs) targeting PD1 are highly active in relapsed/refractory classical Hodgkin lymphoma. A plethora of recent studies, often small and non-randomised, have raised many questions about how to optimally integrate these into clinical practice. We aim to discuss the use of CPIs in different relapsed/refractory settings in an effort to better define their role and highlight areas of research.
View Article and Find Full Text PDFHyperacute Graft-Versus-Host Disease Mimicking Stevens-Johnson Syndrome in a Patient With Allogeneic Hematopoietic Stem Cell Transplantation.
Dermatol Pract Concept
May 2022
Department of Dermatology and Venereology, Hacettepe University, Faculty of Medicine, Ankara, Turkey.
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