Evaluating the heart global function from magnetic resonance images is based on estimating a number of functional parameters such as the left ventricular (LV) volume, LV mass, ejection fraction, and stroke volume. Estimating these parameters requires accurate calculation of the volumes enclosed by the inner and outer surfaces of the LV chamber at the max contraction and relaxation states of the heart. Currently, this is achieved through acquisition and segmentation of a large number of short-axis (SAX) views of the LV, which is time-consuming and expensive. Reducing the number of acquisitions results in undersampling the LV surfaces and hence increases the calculation errors. In this work, we describe and evaluate a method for estimating the cardiac parameters from a small number of image acquisitions that includes one long-axis (LAX) view of the LV. In this method, the LAX contour is used to swipe the SAX contours to fill in the missed LV surface between the SAX slices. Results on 25 patients and CT phantoms shows that, given the same number of slices, the proposed method is superior to other methods.
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http://dx.doi.org/10.1109/EMBC.2014.6945172 | DOI Listing |
Objective: Scleroderma-associated autoantibodies (SSc-Abs) are specific in participants (pts) with systemic sclerosis and are associated with organ involvement. Our objective was to assess the influence of baseline SSc-Abs on the trajectories of the clinical outcome assessments (COAs) in a phase III randomized controlled trial.
Methods: We used data on both the groups who received placebo (Pbo) and tocilizumab from the focuSSced trial.
Glob Chang Biol
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Aquatic Ecology, Department Biology, Ludwig-Maximilians - University Munich, München, Germany.
Plankton biodiversity is crucial for the functioning of aquatic ecosystems, influencing nutrient cycling, food web dynamics, and carbon storage. Global change and habitat destruction disrupt these ecosystems, reducing species diversity and ecosystem resilience. Connectivity between aquatic habitats supports biodiversity by enabling species migration, genetic diversity, and recovery from disturbances.
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November 2024
Institute of Biochemistry and Molecular Medicine, University of Bern, Bern 3012, Switzerland.
Summary: Protein structure prediction aims to infer a protein's three-dimensional (3D) structure from its amino acid sequence. Protein structure is pivotal for elucidating protein functions, interactions, and driving biotechnological innovation. The deep learning model AlphaFold2, has revolutionized this field by leveraging phylogenetic information from multiple sequence alignments (MSAs) to achieve remarkable accuracy in protein structure prediction.
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January 2025
Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, China.
Cholangiocarcinoma is the second most common primary liver cancer, and its global incidence has increased in recent years. Radical surgical resection and systemic chemotherapy have traditionally been the standard treatment options. However, the complexity of cholangiocarcinoma subtypes often presents a challenge for early diagnosis.
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January 2025
Department of Pathology, Microbiology & Immunology, New York Medical College, Valhalla, NY, United States.
Rationale: Approximately 32 million people in the United States suffer from food allergies. Some food groups, such as legumes - peanuts, tree nuts, fish, and shellfish, have a high risk of cross-reactivity. However, the murine model of multiple food group cross-reactivity is limited.
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