In muscle dystrophy studies, registration of histological image with MRI image volume enables cross validation of MRI biomarkers using pathological result. However, correlation of 2D histology slice with 3D MRI volume is technically challenging due to the potentially non-orthogonal slice plane and incomplete or distorted histological slice. This paper presents an efficient method to directly perform the 2D-3D registration. The method is unique in that it uses smart phone as a navigation tool for initial alignment followed by an overlap invariant mutual information-based refinement. Experimental results using animal muscle samples images from a 3T MRI and HE stained histological images show that the proposed method is capable of aligning the histological slice with an oblique slice in MR volume.
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