In this work, we describe a new method, an extension of the Large Deformation Diffeomorphic Metric Mapping to estimate three-dimensional deformation of tagged Magnetic Resonance Imaging Data. Our approach relies on performing non-rigid registration of tag planes that were constructed from set of initial reference short axis tag grids to a set of deformed tag curves. We validated our algorithm using in-vivo tagged images of normal mice. The mapping allows us to compute root mean square distance error between simulated tag curves in a set of long axis image planes and the acquired tag curves in the same plane. Average RMS error was 0.31 ± 0.36(SD) mm, which is approximately 2.5 voxels, indicating good matching accuracy.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4474039PMC
http://dx.doi.org/10.1109/EMBC.2014.6944772DOI Listing

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