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Invariant natural killer T cells generated from human adult hematopoietic stem-progenitor cells are poly-functional. | LitMetric

Invariant natural killer T cells generated from human adult hematopoietic stem-progenitor cells are poly-functional.

Cytokine

Department of Microbiology and Immunology, University of Maryland School of Medicine, and the Marlene and Stewart Greenebaum Cancer Center, Baltimore, MD 21201, United States. Electronic address:

Published: March 2015

AI Article Synopsis

Article Abstract

Invariant natural killer T (iNKT) cells constitute an important subset of T cells that can both directly and indirectly mediate anti-tumor immunity. However, cancer patients have a reduction in both iNKT cell number and function, and these deficits limit the potential clinical application of iNKT cells for cancer therapy. To overcome the problem of limited iNKT cell numbers, we investigated whether iNKT cells can be generated in vitro from bone marrow-derived adult hematopoietic stem-progenitor cells (HSPC). Our data demonstrate that co-culture of HSPC with OP9-DL1 stromal cells, results in a functional CD3(+) T cell population. These T cells can be further differentiated into iNKT cells by secondary culture with CD1d-Ig-based artificial antigen-presenting cells (aAPC). Importantly, these in vitro-generated iNKT cells are functional, as demonstrated by their ability to proliferate and secrete IFN-γ and GM-CSF following stimulation.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4329102PMC
http://dx.doi.org/10.1016/j.cyto.2014.12.009DOI Listing

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