AI Article Synopsis
- Marginal zone lymphoma (MZL) is the third most common type of B-cell non-Hodgkin lymphoma.
- A two-stage genome-wide association study (GWAS) of 1,281 MZL cases and 7,127 controls identified significant genetic loci associated with MZL near the BTNL2 and HLA-B genes.
- This study provides the first evidence that variations in the major histocompatibility complex can influence a person's risk of developing MZL.
Article Abstract
Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci near BTNL2 (rs9461741, P=3.95 × 10(-15)) and HLA-B (rs2922994, P=2.43 × 10(-9)) in the HLA region significantly associated with MZL risk. This is the first evidence that genetic variation in the major histocompatibility complex influences MZL susceptibility.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4287989 | PMC |
| http://dx.doi.org/10.1038/ncomms6751 | DOI Listing |
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