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Intercellular communication by extracellular vesicles with emphasis on the roles of cordocytes in the human brain. An ultrastructural study. | LitMetric

AI Article Synopsis

  • - This study highlights the presence of extracellular vesicles (EVs), particularly in cordocytes, across various brain conditions using transmission electron microscopy (TEM).
  • - EVs play a crucial role in cell communication and functions among brain cells, impacting processes like cell activation and cancer progression.
  • - The findings suggest that EVs are significant modulators of cell activities and indicate a need for further research to better understand their roles in brain health and disease.

Article Abstract

We describe in this work the presence of extracellular vesicles (EVs) along different cell types, especially cordocytes, in various clinical conditions of the human brain (atherothrombotic disease, cerebral tumors, hygroma durae matris, intracerebral cysts, Moyamoya disease and parenchymatous hematoma) using transmission electron microscopy (TEM). EVs, illustrated as exosomes and microvesicles, were causally related to cell-to-cell communication, and other vital functions of resident cells around the brain parenchyma, either around the cortical vessels or into the subarachnoid space and the reticular arachnoid. Our direct demonstration by TEM of these information transporters in all locations and situations where the cordocytes play coordinating and regulating roles, producing and delivering a significant number of EVs to their targets, remains to be better documented in future studies. This first study on this topic showed clearly that EVs can be important modulators of cell functions with roles in cell activation, differentiation, phenotypic change, cancer progression, from precursor/stem cells to tumoral phenotypes, because EVs are released en masse during key interactions and certain moments.

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Source
http://dx.doi.org/10.3109/01913123.2014.981327DOI Listing

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