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Indocyanine green-loaded nanoparticles for image-guided tumor surgery. | LitMetric

Indocyanine green-loaded nanoparticles for image-guided tumor surgery.

Bioconjug Chem

Virginia Tech - Wake Forest University School of Biomedical Engineering and Sciences, ‡Wake Forest Institute for Regenerative Medicine, §Department of Cancer Biology, Wake Forest University Health Sciences, Winston-Salem, North Carolina 27157, United States ;

Published: February 2015

AI Article Synopsis

Article Abstract

Detecting positive tumor margins and local malignant masses during surgery is critical for long-term patient survival. The use of image-guided surgery for tumor removal, particularly with near-infrared fluorescent imaging, is a potential method to facilitate removing all neoplastic tissue at the surgical site. In this study we demonstrate a series of hyaluronic acid (HLA)-derived nanoparticles that entrap the near-infrared dye indocyanine green, termed NanoICG, for improved delivery of the dye to tumors. Self-assembly of the nanoparticles was driven by conjugation of one of three hydrophobic moieties: aminopropyl-1-pyrenebutanamide (PBA), aminopropyl-5β-cholanamide (5βCA), or octadecylamine (ODA). Nanoparticle self-assembly, dye loading, and optical properties were characterized. NanoICG exhibited quenched fluorescence that could be activated by disassembly in a mixed solvent. NanoICG was found to be nontoxic at physiologically relevant concentrations and exposure was not found to inhibit cell growth. Using an MDA-MB-231 tumor xenograft model in mice, strong fluorescence enhancement in tumors was observed with NanoICG using a fluorescence image-guided surgery system and a whole-animal imaging system. Tumor contrast with NanoICG was significantly higher than with ICG alone.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4373659PMC
http://dx.doi.org/10.1021/bc5005679DOI Listing

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