AI Article Synopsis
- Thousands of long noncoding RNAs (lncRNAs) have been identified, but researching their functions is challenging due to a lack of adequate tools.
- Researchers are exploring new RNA-focused methods to analyze lncRNA structure, location in the genome, and their biochemical interactions.
- Advancing these technologies is crucial for moving from simply identifying lncRNAs to understanding their various roles in biological processes.
Article Abstract
Thousands of long noncoding RNAs (lncRNAs) have been discovered, but their functional characterization has been slowed by a limited set of research tools. Here we review emerging RNA-centric methods to interrogate the intrinsic structure of lncRNAs as well as their genomic localization and biochemical partners. Understanding these technologies, including their advantages and caveats, and developing them in the future will be essential to progress from description to comprehension of the myriad roles of lncRNAs.
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| http://dx.doi.org/10.1038/nsmb.2921 | DOI Listing |
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