Isocyanates and human health: multistakeholder information needs and research priorities.

J Occup Environ Med

From the Department of Environmental Health (Dr Lockey), Division of Occupational and Environmental Medicine, Pulmonary Division--Department of Internal Medicine, University of Cincinnati College of Medicine, Ohio; Yale Occupational and Environmental Medicine (Dr Redlich), Yale School of Medicine, New Haven, Conn; Division of Applied Research and Technology (Dr Streicher), National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio; Risk Assessment Division (Ms Pfahles-Hutchens), Office of Chemical Safety and Pollution Prevention, US Environmental Protection Agency, Washington, DC; Office of Clinical Toxicology (Dr Hakkinen), Specialized Information Services, National Library of Medicine, National Institutes of Health; Epidemiology and Genomics Research Program (Dr Ellison), Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Md; Mel and Enid Zuckerman College of Public Health (Dr Harber), University of Arizona, Tucson; Occupational and Environmental Medicine (Dr Utell), University of Rochester Medical Center, NY; Holland Associates (Dr Holland), Palo Alto, Calif; International Union (Mr Comai), UAW, Health and Safety, Detroit, Mich; and Department of Family Practice (Dr White), University of British Columbia, and Canadian Institute for the Relief of Pain and Disability, Vancouver, Canada.

Published: January 2015

Objectives: To outline the knowledge gaps and research priorities identified by a broad base of stakeholders involved in the planning and participation of an international conference and research agenda workshop on isocyanates and human health held in Potomac, Maryland, in April 2013.

Methods: A multimodal iterative approach was used for data collection including preconference surveys, review of a 2001 consensus conference on isocyanates, oral and poster presentations, focused break-out sessions, panel discussions, and postconference research agenda workshop.

Results: Participants included representatives of consumer and worker health, health professionals, regulatory agencies, academic and industry scientists, labor, and trade associations.

Conclusions: Recommendations were summarized regarding knowledge gaps and research priorities in the following areas: worker and consumer exposures; toxicology, animal models, and biomarkers; human cancer risk; environmental exposure and monitoring; and respiratory epidemiology and disease, and occupational health surveillance.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4286799PMC
http://dx.doi.org/10.1097/JOM.0000000000000278DOI Listing

Publication Analysis

Top Keywords

isocyanates human
8
human health
8
knowledge gaps
8
gaps priorities
8
health
5
health multistakeholder
4
multistakeholder priorities
4
priorities objectives
4
objectives outline
4
outline knowledge
4

Similar Publications

Vegetables containing sulfur compounds promote trans-isomerization of unsaturated fatty acids in triacylglycerols during the cooking process.

Food Res Int

January 2025

Faculty of Science & Technology, Meijo University, 1-501 Shiogamaguchi, Tempaku-ku, Nagoya, Aichi 468-8502, Japan; Graduate School of Environmental and Human Sciences, Meijo University, 1-501 Shiogamaguchi, Tempaku-ku, Nagoya, Aichi 468-8502, Japan. Electronic address:

Growing evidence indicates that the intake of trans-fatty acids (TFAs) has been associated with a higher risk of cardiovascular disease; therefore, various industrial measures have been taken to reduce the amount of TFAs consumed. However, research on TFAs formed during cooking is limited. Isothiocyanates and polysulfides, which are widely distributed in various vegetables, have recently been shown to promote the cis-trans isomerization of double bonds.

View Article and Find Full Text PDF

The Anti-AGEing and RAGEing Potential of Isothiocyanates.

Molecules

December 2024

Department of Surgery, School of Medicine, Virginia Commonwealth University, Richmond, VA 23284, USA.

Isothiocyanates (ITCs), found in edible plants such as cruciferous vegetables, are a group of reactive organo-sulfur phytochemicals produced by the hydrolysis of precursors known as glucosinolates. ITCs have been studied extensively both in vivo and in vitro to define their therapeutic potential for the treatment of chronic health conditions. Therapeutically, they have shown an intrinsic ability to inhibit oxidative and inflammatory phenotypes to support enhanced health.

View Article and Find Full Text PDF

Isothiocyanates (ITCs) are naturally occurring sulfur-containing compounds with diverse biological effects. This study investigated the effects of sulforaphane (SFN, an aliphatic ITC) and benzyl isothiocyanate (BITC, an aromatic ITC) on human acute myeloid leukemia SKM-1 cells, focusing on cell proliferation, cell death, and drug resistance. Both drug-sensitive SKM-1 cells and their drug-resistant SKM/VCR variant, which overexpresses the drug transporter P-glycoprotein, were used.

View Article and Find Full Text PDF

Black rice (BR) is beneficial for the health of animals and humans. Herein, we investigated the pharmacokinetics of cyanidin-3-glucoside (C3G), a major anthocyanin constituent of BR, in male rats. After its intravenous administration, C3G was rapidly distributed throughout the body and disappeared from the plasma.

View Article and Find Full Text PDF

Food-derived components with physiological effects have been attracting attention in recent years, and studies have comprehensively analyzed these components. In this study, we sought to identify food components with functional properties for the prevention and improvement of metabolic syndrome. We performed a luciferase reporter assay using fatty acid synthase (FAS) and low-density lipoprotein receptor (LDL) receptor gene promoters.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!