The Drosophila neoplastic tumor suppressor Lethal giant larvae (Lgl) regulates apico-basal polarity in epithelia as well as the asymmetric segregation of cell fate in neural progenitors. Two new studies uncover a new facet of its regulation in epithelia, where Aurora-dependent phosphorylation triggers Lgl dissociation from the basolateral cortex to facilitate planar orientation of the mitotic spindle.
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| http://dx.doi.org/10.1016/j.cub.2014.11.052 | DOI Listing |
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